Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals

J Zhang, Q Wu, Z Liu, Q Wang, J Wu, Y Hu, T Bai… - Nature …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2),–and individuals with COVID-19 have …

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells

CR Pothast, RC Dijkland, M Thaler, RS Hagedoorn… - Elife, 2022 - elifesciences.org
Detection of SARS-coronavirus-2 (SARS-CoV-2) specific CD4+ and CD8+ T cells in SARS-
CoV-2-unexposed donors has been explained by the presence of T cells primed by other …

[HTML][HTML] Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

A Tarke, J Sidney, N Methot, ED Yu, Y Zhang… - Cell Reports …, 2021 - cell.com
The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the
importance of addressing whether the total CD4+ and CD8+ T cell recognition is also …

Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination

Y Gao, C Cai, D Wullimann, J Niessl… - Immunity, 2022 - cell.com
Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2
mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells …

Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variants

B Kingstad-Bakke, W Lee… - Proceedings of the …, 2022 - National Acad Sciences
The first-generation COVID-19 vaccines have been effective in mitigating severe illness and
hospitalization, but recurring waves of infections are associated with the emergence of …

Children and adults with mild COVID-19: dynamics of the memory T cell response up to 10 months

P Kaaijk, V Olivo Pimentel, ME Emmelot… - Frontiers in …, 2022 - frontiersin.org
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to
considerable morbidity/mortality worldwide, but most infections, especially among children …

Cell‐mediated and humoral adaptive immune responses to SARS‐CoV‐2 are lower in asymptomatic than symptomatic COVID‐19 patients

A Mazzoni, L Maggi, M Capone… - European Journal of …, 2020 - Wiley Online Library
The characterization of cell‐mediated and humoral adaptive immune responses to SARS‐
CoV‐2 is fundamental to understand COVID‐19 progression and the development of …

T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

SJ Choi, DU Kim, JY Noh, S Kim, SH Park… - Cellular & molecular …, 2022 - nature.com
In November 2021, the Omicron variant (B. 1.1. 529) emerged and was designated a variant
of concern (VOC) by the World Health Organization. Recently, Omicron was reported to …

Defending against SARS-CoV-2: The T cell perspective

P Almendro-Vázquez, R Laguna-Goya… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …

Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?

SJ Kent, DS Khoury, A Reynaldi, JA Juno… - Nature Reviews …, 2022 - nature.com
The rapid development of multiple vaccines providing strong protection from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …