Various cells in the body are capable of sensing infectious viruses and initiating reactions
collectively known as antiviral innate responses. These responses include the production of …

RIG-I is an essential innate immune receptor for detecting and responding to infection by
RNA viruses. RIG-I specifically recognizes the unique molecular features of viral RNA …

ABSTRACT RIG-I-like receptors (RLRs) play important roles in the host defense to
numerous viral pathogens. Since they were discovered, much light has been shed on the …

During virus infection, multiple immune signaling pathways are triggered, both within the
host cell and bystander cells of an infected tissue. These pathways act in concert to mediate …

RIG-I is essential for host defense against viral pathogens, as it triggers the release of type I
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …

Mammalian cells have the ability to recognize virus infection and mount a powerful antiviral
response. Pattern recognition receptor proteins detect molecular signatures of virus infection …

Vertebrate innate immunity is characterized by an effective immune surveillance apparatus,
evolved to sense foreign structures, such as proteins or nucleic acids of invading microbes …

RIG-I-like receptors (RLRs) are cytosolic innate immune sensors that detect pathogenic RNA
and induce a systemic antiviral response. During the last decade, many studies focused on …

Intracellular RIG-I-like receptors (RLRs, including RIG-I, MDA-5, and LGP2) recognize viral
RNAs as pathogen-associated molecular patterns (PAMPs) and initiate an antiviral immune …

RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …