REGULATION BY TROPONIN-TROPOMYOSIN 537 structural changes cause increased
interaction between actin and myosin, enhanced actomyosin ATPase activity, and …

The molecular switching mechanism governing skeletal and cardiac muscle contraction
couples the binding of Ca2+ on troponin to the movement of tropomyosin on actin filaments …

The molecular regulation of striated muscle contraction couples the binding and dissociation
of Ca2+ on troponin (Tn) to the movement of tropomyosin on actin filaments. In turn, this …

Troponin (Tn), containing three subunits: Ca 2+ binding (TnC), inhibitory (TnI), and
tropomyosin binding (TnT), plays a crucial role in the Ca 2+ regulation of vertebrate striated …

The contraction of skeletal muscle is regulated by Ca 2+ binding to troponin C, which results
in an internal reorganization of the interactions within the troponin-tropomyosin complex …

In a wide variety of cellular settings, from organelle transport to muscle contraction, Ca2+
binding to members of the EF hand family of proteins controls the interaction between actin …

Troponin and tropomyosin on actin filaments constitute a Ca2+-sensitive switch that
regulates the contraction of vertebrate striated muscle through a series of conformational …

It is 30 years since Ebashi and colleagues showed that Ca2+ ions directly affect regulation
of the myosin‐actin interaction in muscle through the action of tropomyosin and troponin on …

Contraction of striated muscles is regulated by tropomyosin strands that run continuously
along actin-containing thin filaments. Tropomyosin blocks myosin-binding sites on actin in …

The steric model of muscle regulation holds that at low Ca2+ concentration, tropomyosin
strands, running along thin filaments, are constrained by troponin in an inhibitory position …