Abstract l-DOPA is the gold-standard treatment for Parkinson's disease (PD), but induces
troublesome dyskinesia after prolonged treatment. This is associated with the 'false …

Glutamatergic dysfunction has been implicated in psychiatric disorders such as
schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been …

Abstract l-3, 4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapy for motor
symptoms of Parkinson's disease (PD); however, with repeated administration, as many as …

Methamphetamine (METH) abuse has become a major public health concern worldwide
without approved pharmacotherapies. The brain renin–angiotensin system (RAS) is …

At h5-HT1A receptors, stably transfected into Chinese Hamster Ovary Cells (CHO-h5-HT1A),
the selective 5-HT1A receptor agonist,(+) 8-hydroxy-dipropyl-amino-tetralin,((+) 8-OH …

Introduction Prepulse inhibition (PPI) of the startle reflex has been extensively studied
because it is disrupted in several psychiatric diseases, most notably schizophrenia. In rats …

Abnormal levels of dopamine (DA) are thought to contribute to several neurological and
psychiatric disorders including drug addiction. Extracellular DA levels are regulated …

Rationale l-DOPA continues to be the primary treatment for patients with Parkinson's
disease; however, the benefits of long-term treatment are often accompanied by debilitating …

Abstract Background Gastrodia elata Blume (GEB), commonly used medicinal herb, has
been reported as a promising candidate for neurodegenerative diseases such as …

Rationale Several studies have shown that swim stress lowers the convulsant potency of
different convulsants. The involvement of α 2-adrenoceptors has been proposed. Drugs …