The fate of developing T cells is specified by the interaction of their antigen receptors with
self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs) …

The ability of T cells to respond to a wide array of foreign antigens while avoiding reactivity
to self is largely determined by cellular selection of developing T cells in the thymus. While a …

To understand how thymic selection gives rise to T cells that are capable of major
histocompatibility complex (MHC)–restricted recognition of antigen but are tolerant of self …

Positive selection to self-MHC/peptide complexes has long been viewed as a device for
skewing the T cell repertoire toward recognition of foreign peptides presented by self-MHC …

Intrathymic self-peptide–major histocompatibility complex class II (MHC) molecules shape
the T cell repertoire through positive and negative selection of immature CD4+ CD8+ …

Michael J. Bevan cells of the thymus are the cells responsible for pre-Howard Hughes
Medical Institute senting MHC ligands to immature T cells. Lethally irradi-Department of …

Understanding how thymic selection imparts self-peptide–MHC complex restriction and a
high degree of self tolerance on the T cell repertoire requires a detailed description of the …

There is a long-standing assumption that naive CD4+ and CD8+ T cells are largely
homogeneous populations despite the extraordinary diversity of their T cell receptors (TCR) …

Our perception of the scope self-antigen availability for tolerance induction in the thymus has
profoundly changed over the recent years following new insights into the cellular and …

Abstract CD4+ CD8+ thymocyte differentiation requires TCR signaling induced by self-
peptide/MHC ligands. Nevertheless, the resulting mature T cells are not activated by these …