A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
[HTML][HTML] The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
[HTML][HTML] Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis
Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …
information to the next generation. Although extensively studied in mice, our current …
Decoding the spermatogenesis program: new insights from transcriptomic analyses
Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …
Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis
A systematic interrogation of male germ cells is key to complete understanding of molecular
mechanisms governing spermatogenesis and the development of new strategies for …
mechanisms governing spermatogenesis and the development of new strategies for …
Characterization of germ cell differentiation in the male mouse through single-cell RNA sequencing
S Lukassen, E Bosch, AB Ekici, A Winterpacht - Scientific reports, 2018 - nature.com
Spermatogenesis in the mouse has been extensively studied for decades. Previous
methods, such as histological staining or bulk transcriptome analysis, either lacked …
methods, such as histological staining or bulk transcriptome analysis, either lacked …
What has single-cell RNA-seq taught us about mammalian spermatogenesis?
S Suzuki, VD Diaz, BP Hermann - Biology of Reproduction, 2019 - academic.oup.com
Mammalian spermatogenesis is a complex developmental program that transforms mitotic
testicular germ cells (spermatogonia) into mature male gametes (sperm) for production of …
testicular germ cells (spermatogonia) into mature male gametes (sperm) for production of …
Unraveling transcriptome dynamics in human spermatogenesis
SZ Jan, TL Vormer, A Jongejan, MD Röling… - …, 2017 - journals.biologists.com
Spermatogenesis is a dynamic developmental process that includes stem cell proliferation
and differentiation, meiotic cell divisions and extreme chromatin condensation. Although …
and differentiation, meiotic cell divisions and extreme chromatin condensation. Although …
Single-cell RNA sequencing of adult mouse testes
S Lukassen, E Bosch, AB Ekici, A Winterpacht - Scientific data, 2018 - nature.com
Spermatogenesis is an efficient and complex system of continuous cell differentiation.
Previous studies investigating the transcriptomes of different cell populations in the testis …
Previous studies investigating the transcriptomes of different cell populations in the testis …
The adult human testis transcriptional cell atlas
Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …