Our understanding of estrogen signaling has undergone a true paradigm shift over recent
years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor β …

The biological actions of estrogens are mediated by estrogen binding to one of two specific
estrogen receptors (ERs) ERα and ERβ, which belong to the nuclear receptor superfamily, a …

The discovery of a second estrogen receptor (ER), designated ERβ (NR3A2), has redefined
our knowledge about the mechanisms underlying cellular signaling by estrogens and has …

The discovery of ERβ in the middle of the 1990s represents a paradigm shift in our
understanding of estrogen signaling. It has turned out that estrogen action is not mediated …

The discovery of the second estrogen receptor (ER) in 1995 surprised many
endocrinologists and resulted in some scepticism regarding its physiological importance …

We have known for many years that estrogen is more than the female hormone. It is
essential in the male gonads, and in both sexes, estrogen has functions in the skeleton and …

The unexpected discovery of a second form of the estrogen receptor (ER), designated ERβ,
surprised and energized the field of estrogen research. In the 9 yr since its identification, the …

Estrogen receptor β (ERβ) was discovered in 1995 and reported on in 1996. During the 10
years following this event, our understanding of estrogen signaling has changed …

During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

Together with the estrogen receptor (ER) alpha, estrogen receptor beta (ERβ) mediates
many of the physiological effects of estrogens. As ERβ is crucially involved in a variety of …