NF-κB in cancer: from innocent bystander to major culprit
M Karin, Y Cao, FR Greten, ZW Li - Nature reviews cancer, 2002 - nature.com
Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …
involved in the inflammatory and innate immune responses. Although the importance of NF …
The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation
S Gerondakis, R Grumont, I Rourke… - Current opinion in …, 1998 - Elsevier
The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene
expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear …
expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear …
[引用][C] NF-κ B and chemoresistance: Potentiation of cancer drugs via inhibition of NF-κ B
JC Cusack, R Liu, AS Baldwin - Drug Resistance Updates, 1999 - Elsevier
1Lineberger Comprehensive Cancer Center, 2Department of Surgery, University of North
Carolina School of Medicine, NC, USA he transcription factor NF-κB is an intensively studied …
Carolina School of Medicine, NC, USA he transcription factor NF-κB is an intensively studied …
[HTML][HTML] Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …
regulation of a large number of genes that are involved in important physiological …
NF-κB and the immune response
One of the primary physiological roles of nuclear factor-kappa B (NF-κB) is in the immune
system. In particular, NF-κB family members control the transcription of cytokines and …
system. In particular, NF-κB family members control the transcription of cytokines and …
[HTML][HTML] Caspase-3-mediated cleavage of the NF-κB subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis
KH Kang, KH Lee, MY Kim, KH Choi - Journal of Biological Chemistry, 2001 - ASBMB
The transcription factor nuclear factor κB (NF-κB) plays a crucial role in immune and
inflammatory response, and protects cells from apoptosis. In this report, we investigate …
inflammatory response, and protects cells from apoptosis. In this report, we investigate …
NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
Recent evidence indicates that the transcription factor NF-κB is a major effector of inducible
antiapoptotic mechanisms. For example, it was shown that NF-κB activation suppresses the …
antiapoptotic mechanisms. For example, it was shown that NF-κB activation suppresses the …
NF-κB and cancer: how intimate is this relationship
S Prasad, J Ravindran, BB Aggarwal - Molecular and cellular biochemistry, 2010 - Springer
NF-κB, a transcription factor first discovered in 1986, is now known to be closely connected
to the process of tumorogenesis based on a multiplicity of evidence.(1) NF-κB is activated in …
to the process of tumorogenesis based on a multiplicity of evidence.(1) NF-κB is activated in …
Pharmacological significance of the non-canonical NF-κB pathway in tumorigenesis
D Morgan, M Garg, V Tergaonkar, SY Tan… - Biochimica et Biophysica …, 2020 - Elsevier
The understanding of the impact of the non-canonical NF-κB (nuclear factor kappa-light-
chain-enhancer of activated B cells) pathway in several human diseases including …
chain-enhancer of activated B cells) pathway in several human diseases including …
A structural guide to proteins of the NF-κB signaling module
The prosurvival transcription factor NF-κB specifically binds promoter DNA to activate target
gene expression. NF-κB is regulated through interactions with IκB inhibitor proteins. Active …
gene expression. NF-κB is regulated through interactions with IκB inhibitor proteins. Active …