Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles
In a continuation of our previous work for the exploration of novel enzyme inhibitors, two new
coumarin-thiazole 6 (a–o) and coumarin-oxadiazole 11 (a–h) hybrids have been designed …
coumarin-thiazole 6 (a–o) and coumarin-oxadiazole 11 (a–h) hybrids have been designed …
Synthesis, biological evaluation and molecular modeling studies of phthalazin-1 (2 H)-one derivatives as novel cholinesterase inhibitors
A new series of donepezil analogues based on the phthalazin-1 (2H)-one scaffold was
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids
The major enzyme responsible for the hydrolytic breakdown of the neurotransmitter
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
In-vitro evaluation and in-silico studies applied on newly synthesized amide derivatives of N-phthaloylglycine as Butyrylcholinesterase (BChE) inhibitors
S Begum, SS Nizami, U Mahmood, S Masood… - … Biology and Chemistry, 2018 - Elsevier
Amide derivatives of N-phthaloylglycine were synthesized under Schotten Baumann
reaction condition. The structures of synthesized compounds (4a–d) were characterized by …
reaction condition. The structures of synthesized compounds (4a–d) were characterized by …
Multi-combined QSAR, molecular docking, molecular dynamics simulation, and ADMET of Flavonoid derivatives as potent cholinesterase inhibitors
H Soufi, M Moussaoui, S Baammi… - Journal of …, 2023 - Taylor & Francis
In searching for a new and efficient therapeutic agent against Alzheimer's disease, a
Quantitative structure-activity relationship (QSAR) was derived for 45 Flavonoid derivatives …
Quantitative structure-activity relationship (QSAR) was derived for 45 Flavonoid derivatives …
Quinoline containing chalcone derivatives as cholinesterase inhibitors and their in silico modeling studies
MS Shah, M Najam-ul-Haq, HS Shah, SUF Rizvi… - … Biology and Chemistry, 2018 - Elsevier
Cholinesterases (ChEs) play a vital role in regulating cholinergic transmission. Inhibition of
ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative …
ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative …
Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives
WR Mahmoud, YM Nissan, MM Elsawah… - European Journal of …, 2019 - Elsevier
Twenty four 6-aminocoumarin based derivatives were synthesized according to two
schemes. All the compounds were screened for their acetylcholinesterase inhibitory activity …
schemes. All the compounds were screened for their acetylcholinesterase inhibitory activity …
Multi-target approach for Alzheimer's disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4-N-phenylaminoquinoline …
FY Adeowo, MA Ejalonibu, AA Elrashedy… - Journal of …, 2021 - Taylor & Francis
The identification of dual inhibitors targeting the active sites of the cholinesterase enzymes,
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), have lately surfaced as a …
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), have lately surfaced as a …