Anti-cholinesterase activity of chalcone derivatives: synthesis, in vitro assay and molecular docking study
Background: Chalcones, originated from natural product, have been broadly studied their
biological activity against various proteins which at the molecular level, are responsible for …
biological activity against various proteins which at the molecular level, are responsible for …
Identification of a novel dual inhibitor of acetylcholinesterase and butyrylcholinesterase: in vitro and in silico studies
RBM de Almeida, DB Barbosa, MR do Bomfim… - Pharmaceuticals, 2023 - mdpi.com
The enhancement of cholinergic functions via acetylcholinesterase (AChE) and
butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for …
butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for …
Synthesis, molecular docking and cholinesterase inhibitory activity of hydroxylated 2-phenylbenzofuran derivatives
We have designed, synthesized and evaluated a series of hydroxylated 2-phenylbenzofuran
derivatives as potential cholinesterase inhibitors. Starting from a series of 2 …
derivatives as potential cholinesterase inhibitors. Starting from a series of 2 …
Amino-7, 8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro …
A Asadipour, Y Pourshojaei, M Mansouri… - BMC chemistry, 2024 - Springer
In this article, we present the design and synthesis of amino-7, 8-dihydro-4H-chromenone
derivatives as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase …
derivatives as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase …
In vitro and in silico correlation of benzoxazole-based thiazolidinone hybrids derivatives: A promising acetylcholinesterase and butyrylcholinesterase inhibitors
Benzoxazole-based thiazolidinone hybrids derivatives (1–19) were afforded and further
subjected to in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
subjected to in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
Synthesis, anticholinesterase activity and molecular modeling studies of novel carvacrol-substituted amide derivatives
In the present study, 23 novel carvacrol derivatives involving the amide moiety as a linker
between the alkyl chains and/or the heterocycle nucleus were synthesized and tested in …
between the alkyl chains and/or the heterocycle nucleus were synthesized and tested in …
Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities
W Luo, Y Chen, T Wang, C Hong, LP Chang… - Bioorganic & Medicinal …, 2016 - Elsevier
A novel series of 7-aminoalkyl-substituted flavonoid derivatives 5a–5r were designed,
synthesized and evaluated as potential cholinesterase inhibitors. The results showed that …
synthesized and evaluated as potential cholinesterase inhibitors. The results showed that …
Synthesis of 2‐(2‐oxo‐2H‐chromen‐4‐yl)acetamides as potent acetylcholinesterase inhibitors and molecular insights into binding interactions
J Kara, P Suwanhom, C Wattanapiromsakul… - Archiv der …, 2019 - Wiley Online Library
Sixteen novel coumarin‐based compounds are reported as potent acetylcholinesterase
(AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04±0.01 µM) …
(AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04±0.01 µM) …
Synthesis, in vitro biological evaluation and in silico molecular docking studies of indole based thiadiazole derivatives as dual inhibitor of acetylcholinesterase and …
The current study was conducted to obtain hybrid analogues of indole-based thiadiazole
derivatives (1–16) in which a number of reaction steps were involved. To examine their …
derivatives (1–16) in which a number of reaction steps were involved. To examine their …
Sulfonylbis (acylhydrazones) as anticholinesterase inhibitors: Synthesis, in vitro biological evaluation and computational studies
This current research work is focused on the synthesis of sulfonyl-mediated hydrazones, its
exploration as anticholinesterase inhibitors, in vitro biological evaluation, and computational …
exploration as anticholinesterase inhibitors, in vitro biological evaluation, and computational …