Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase …
X Lu, Y Li, Q Guan, H Yang, Y Liu, C Du… - ACS Chemical …, 2024 - ACS Publications
For the potential therapy of Alzheimer's disease (AD), butyrylcholinesterase (BChE) has
gradually gained worldwide interest in the progression of AD. This study used a …
gradually gained worldwide interest in the progression of AD. This study used a …
In vitro and in silico correlation of bis-thiazole based Schiff base hybrids analogues: A computational approach develop to promising acetylcholinesterase and …
We have synthesized sixteen bis-thiazole based Schiff bases hybrid derivatives (1–16) and
evaluated against acetylcholinesterase and butyrylcholinesterase enzymes. All analogues …
evaluated against acetylcholinesterase and butyrylcholinesterase enzymes. All analogues …
[HTML][HTML] Natural coumarins from Murraya paniculata as mixed-type inhibitors of cholinesterases: In vitro and in silico investigations
Currently, acetylcholinesterase (AChE) inhibiting drugs in clinical use, such as tacrine,
donepezil, rivastigmine, and galanthamine, are associated with serious side effects and …
donepezil, rivastigmine, and galanthamine, are associated with serious side effects and …
Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
Abstract Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are
interesting compounds for different therapeutic applications, among which Alzheimer's …
interesting compounds for different therapeutic applications, among which Alzheimer's …
[HTML][HTML] Vitamin B3-based biologically active compounds as inhibitors of human cholinesterases
A Zandona, G Lihtar, N Maraković, K Miš… - International journal of …, 2020 - mdpi.com
We evaluated the potential of nine vitamin B3 scaffold-based derivatives as
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point …
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point …
Selective cholinesterase inhibitors from Buxus sempervirens L. and their molecular docking studies
In this work, two alkaloids namely (+)-buxabenzamidienine (1) and (+)-buxamidine (2) were
isolated from Buxus sempervirens, using bioassay-guided fractionation and isolation …
isolated from Buxus sempervirens, using bioassay-guided fractionation and isolation …
[HTML][HTML] Novel 1, 2, 4-oxadiazole derivatives as selective butyrylcholinesterase inhibitors: Design, synthesis and biological evaluation
M Nazari, E Rezaee, R Hariri, T Akbarzadeh… - EXCLI …, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive mental disorder that brings a huge economic
burden to the healthcare systems. During this illness, acetylcholine levels in the cholinergic …
burden to the healthcare systems. During this illness, acetylcholine levels in the cholinergic …
Design and synthesis of new dual binding site cholinesterase inhibitors: in vitro inhibition studies with in silico docking
M Yar, M Bajda, R Atif Mehmood… - Letters in drug …, 2014 - ingentaconnect.com
Cholinesterases (ChEs) play a vital role in the regulation of cholinergic transmission. The
inhibition of ChEs is considered to be involved in increasing acetylcholine level in the brain …
inhibition of ChEs is considered to be involved in increasing acetylcholine level in the brain …
Synthesis and bio-evaluation of a novel selective butyrylcholinesterase inhibitor discovered through structure-based virtual screening
S Xing, Y Chen, B Xiong, W Lu, Q Li, Y Wang… - International Journal of …, 2021 - Elsevier
In recent years, butyrylcholinesterase (BChE) has gradually gained worldwide interests as a
novel target for treating Alzheimer's disease (AD). Here, two pharmacophore models were …
novel target for treating Alzheimer's disease (AD). Here, two pharmacophore models were …
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl) thiazol-4yl) methyl) benzo [d][1, 3] dioxole-5-carboxamides as …
M Xi, C Feng, K Du, W Lv, C Du, R Shen… - Bioorganic & Medicinal …, 2022 - Elsevier
Butyrylcholinesterase (BuChE) is recently regarded as a biomarker in progressed
Alzheimer's disease (AD). Development of selective BuChE inhibitors has attracted a great …
Alzheimer's disease (AD). Development of selective BuChE inhibitors has attracted a great …