Chalcone scaffolds exhibiting acetylcholinesterase enzyme inhibition: Mechanistic and computational investigations
This study was aimed to perform the mechanistic investigations of chalcone scaffold as
inhibitors of acetylcholinesterase (AChE) enzyme using molecular docking and molecular …
inhibitors of acetylcholinesterase (AChE) enzyme using molecular docking and molecular …
Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletillastriata as butyrylcholinesterase inhibitors
As part of our continuous studies on natural cholinesterase inhibitors from plant kingdom,
the 95% ethanol extract from tubers of Bletilla striata showed promising …
the 95% ethanol extract from tubers of Bletilla striata showed promising …
Discovery of novel coumarin-schiff base hybrids as potential acetylcholinesterase inhibitors: design, synthesis, enzyme inhibition, and computational studies
AH Hasan, FA Abdulrahman, AJ Obaidullah… - Pharmaceuticals, 2023 - mdpi.com
To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
Combined QSAR, molecular docking and molecular dynamics study on new Acetylcholinesterase and Butyrylcholinesterase inhibitors
Background and purpose This work deals with several molecular modeling methods used to
discover new therapeutic agents for treating the Alzheimer's disease (AD). The cholinergic …
discover new therapeutic agents for treating the Alzheimer's disease (AD). The cholinergic …
Novel series of triazole containing coumarin and isatin based hybrid molecules as acetylcholinesterase inhibitors
Novel series of coumarin-triazole and isatin-triazole hybrids were rationally designed,
synthesized and biologically evaluated to check their inhibitory potential against …
synthesized and biologically evaluated to check their inhibitory potential against …
Design, synthesis and molecular docking simulation of oxindole-based derivatives with dual VEGFR-2 and cholinesterase inhibitory activities
AM Srour, DH Dawood, ES Nossier… - Journal of Molecular …, 2023 - Elsevier
Oxindole-based compounds are deemed to be an interesting scaffold with significant
VEGFR-2 and cholinesterase inhibitory properties. Regarding the studies that displayed the …
VEGFR-2 and cholinesterase inhibitory properties. Regarding the studies that displayed the …
Acetylcholinesterase inhibitory activities of some flavonoids from the root bark of Pinus krempfii Lecomte: in vitro and in silico study
From the root bark of Pinus krempfii Lecomte, four flavonoids were isolated and evaluated
for their inhibitory activities against AChE and BChE enzymes in vitro and in silico …
for their inhibitory activities against AChE and BChE enzymes in vitro and in silico …
Anticholinesterase activities of novel isoindolin-1, 3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study
In pursuit of developing novel cholinesterase (ChE) inhibitors through molecular
hybridization theory, a novel series of isoindolin-1, 3-dione-based acetohydrazides …
hybridization theory, a novel series of isoindolin-1, 3-dione-based acetohydrazides …
Design and synthesis of novel chalcone derivatives and evaluation of their inhibitory activities against acetylcholinesterase
According to the cholinergic hypothesis, an increase in the acetylcholine level in Alzheimer's
disease patients relatively slows down the symptoms of the disease. The most commonly …
disease patients relatively slows down the symptoms of the disease. The most commonly …
Design, synthesis, structure activity relationship and molecular docking studies of thiophene-2-carboxamide Schiff base derivatives of benzohydrazide as novel …
The novel hydrazone derivatives of thiophene-2-carboxamide based benzohydrazide were
designed, synthesized, characterized and explored for their potential as cholinesterase …
designed, synthesized, characterized and explored for their potential as cholinesterase …