[HTML][HTML] New benzotriazole-derived α-substituted hemiaminal ethers with enhanced cholinesterase inhibition activity: synthesis, structural, and biological evaluations
ZM Cheema, M Nisar, HY Gondal, SA Alhussain… - Journal of Saudi …, 2023 - Elsevier
A new series of benzotriazole-derived α-substituted hemiaminal ethers have been
synthesized as human cholinesterase (hChE) inhibitors with enhanced activity. The …
synthesized as human cholinesterase (hChE) inhibitors with enhanced activity. The …
7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
J Korabecny, R Dolezal, P Cabelova, A Horova… - European journal of …, 2014 - Elsevier
A novel series of 7-methoxytacrine (7-MEOTA)–donepezil like compounds was synthesized
and tested for their ability to inhibit electric eel acetylcholinesterase (EeAChE), human …
and tested for their ability to inhibit electric eel acetylcholinesterase (EeAChE), human …
Discovery of novel dual acetylcholinesterase and butyrylcholinesterase inhibitors using machine learning and structure-based drug design
Abstract Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are crucial targets
that catalyse the breakdown of acetylcholine (ACh) and are implicated in the pathogenesis …
that catalyse the breakdown of acetylcholine (ACh) and are implicated in the pathogenesis …
Selective inhibition of human acetylcholinesterase by xanthine derivatives: In vitro inhibition and molecular modeling investigations
The commonly used beverage and psychostimulant caffeine is known to inhibit human
acetylcholinesterase enzyme. This pharmacological activity of caffeine is partly responsible …
acetylcholinesterase enzyme. This pharmacological activity of caffeine is partly responsible …
Design, synthesis, in vitro acetylcholinesterase, butyrylcholinesterase activities, and in silico molecular docking study of oxindole-oxadiazole hybrid analogues
Alzheimer's disease is a neurological disorder characterized by cognitive dysfunction and
deficits in activities of daily living. There is no drug available for Alzheimer's at the moment …
deficits in activities of daily living. There is no drug available for Alzheimer's at the moment …
Exploring indole-based-thiadiazole derivatives as potent acetylcholinesterase and butyrylcholinesterase enzyme inhibitors
Abstract Indole based thiadiazole derivatives (1–18) were synthesized and evaluated for
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …
Exploiting butyrylcholinesterase inhibitors through a combined 3-D pharmacophore modeling, QSAR, molecular docking, and molecular dynamics investigation
S Kumar, A Manoharan, J Jayalakshmi… - RSC …, 2023 - pubs.rsc.org
Alzheimer's disease (AD), a neurodegenerative condition associated with ageing, can occur.
AD gradually impairs memory and cognitive function, which leads to abnormal behavior …
AD gradually impairs memory and cognitive function, which leads to abnormal behavior …
Docking and quantum mechanic studies on cholinesterases and their inhibitors
J Correa-Basurto, C Flores-Sandoval… - European journal of …, 2007 - Elsevier
Docking studies and density functional theory (DFT) calculations were made for 88 N-aryl
derivatives and for some acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) …
derivatives and for some acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) …
1H-benzimidazole derivatives as butyrylcholinesterase inhibitors: synthesis and molecular modeling studies
G Coban, L Carlino, AH Tarikogullari, S Parlar… - Medicinal Chemistry …, 2016 - Springer
Abstract A series of N-{2-[2-(1 H-benzimidazole-2-yl) phenoxy] ethyl} substituted amine
derivatives were synthesized and tested for their cholinesterase inhibitor activity …
derivatives were synthesized and tested for their cholinesterase inhibitor activity …
Cholinesterases inhibition and molecular modeling studies of piperidyl-thienyl and 2-pyrazoline derivatives of chalcones
Super-activation of cholinesterases (acetylcholinesterase and butyrylcholinesterase) are
linked to various neurological problems most precisely Alzheimer's disease (AD), which …
linked to various neurological problems most precisely Alzheimer's disease (AD), which …