[HTML][HTML] 5, 6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety
Background Several studies have been focused on design and synthesis of multi-target anti
Alzheimer compounds. Utilizing of the dual Acetylcholinesterase/Butyrylcholinesterase …
Alzheimer compounds. Utilizing of the dual Acetylcholinesterase/Butyrylcholinesterase …
Exploring indole-based-thiadiazole derivatives as potent acetylcholinesterase and butyrylcholinesterase enzyme inhibitors
Abstract Indole based thiadiazole derivatives (1–18) were synthesized and evaluated for
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …
Screening and identification of secondary metabolites in the bark of Bauhinia variegata to treat Alzheimer's disease by using molecular docking and molecular …
N Khare, SK Maheshwari, AK Jha - Journal of Biomolecular …, 2021 - Taylor & Francis
Abstract Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) acts as a promising
protein targets for which drug as an inhibitor can be designed to treat Alzheimer's Disease …
protein targets for which drug as an inhibitor can be designed to treat Alzheimer's Disease …
7, 8-Dihydroxycoumarin derivatives: In silico molecular docking and in vitro anticholinesterase activity
In this study, acetylcholinesterase enzyme (AChE) inhibition potential and antioxidant
activity of eight different coumarin derivatives together with two (5 and 8) newly synthesized …
activity of eight different coumarin derivatives together with two (5 and 8) newly synthesized …
Design, synthesis, extra-precision docking, and molecular dynamics simulation studies of pyrrolidin-2-one derivatives as potential acetylcholinesterase inhibitors
Inhibition of acetylcholinesterase (AChE) has been widely explored to develop novel
molecules for management of Alzheimer's disease. In past research finding reported …
molecules for management of Alzheimer's disease. In past research finding reported …
Synthesis, characterization, evaluation of metabolic enzyme inhibitors and in silico studies of thymol based 2-amino thiol and sulfonic acid compounds
Eight new aminothiols (4a-g and 5) and three new sulfonic acid derivatives (6a-c) were
synthesized, and their structures were characterized. Inhibitory effects of the obtained …
synthesized, and their structures were characterized. Inhibitory effects of the obtained …
Investigation of potent inhibitors of cholinesterase based on thiourea and pyrazoline derivatives: Synthesis, inhibition assay and molecular modeling studies
Owing to the desperate need of new drugs development to treat Alzheimer's ailment the
synthesis of 1-aroyl-3-(5-(4-chlorophenyl)-1, 2, 4-triazole-3-thioneaminylthioureas (2–6) …
synthesis of 1-aroyl-3-(5-(4-chlorophenyl)-1, 2, 4-triazole-3-thioneaminylthioureas (2–6) …
(⿿)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase
Cholinesterase inhibitors block the bioconversion of neurotransmitters by cholinesterase in
the nervous system. Epicatechin derivatives (1, 3 and 5), polyphenols (6 and 7) from …
the nervous system. Epicatechin derivatives (1, 3 and 5), polyphenols (6 and 7) from …
New azole-derived hemiaminal ethers as promising acetylcholinesterase inhibitors: synthesis, X-ray structures, in vitro and in silico studies
M Nisar, HY Gondal, ZM Cheema… - Journal of …, 2023 - Taylor & Francis
A new class of azole-derived hemiaminal ethers is designed as acetylcholinesterase (AChE)
inhibitors. The synthesized compounds exhibited remarkable inhibitory activity against …
inhibitors. The synthesized compounds exhibited remarkable inhibitory activity against …