Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction

MM Hassan, A Kaseb, CJ Etzel… - Molecular …, 2013 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic with high prevalence in
Western countries. Genome‐wide association studies had reported that a variation in the …

[PDF][PDF] Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta‐analysis of individual participant data

E Trépo, P Nahon, G Bontempi, L Valenti, E Falleti… - …, 2014 - Wiley Online Library
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries.
Although several clinical factors have been identified, many individuals never develop HCC …

Correlation between PNPLA3 rs738409 polymorphism and hepatocellular carcinoma: a meta-analysis of 10,330 subjects

Z Huang, X Guo, G Zhang, L Liang… - … International journal of …, 2019 - journals.sagepub.com
Purpose: The correlation between patatin-like phospholipase domain-containing protein 3
(PNPLA3) rs738409 polymorphism and hepatocellular carcinoma was investigated by …

[HTML][HTML] PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma

L Valenti, BM Motta, G Soardo, M Iavarone, B Donati… - PLoS …, 2013 - journals.plos.org
Background & Aims Aim of this study was to evaluate whether the PNPLA3 I148M
polymorphism, previously associated with hepatocellular carcinoma (HCC) risk, influences …

PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis

E Guyot, A Sutton, P Rufat, C Laguillier, A Mansouri… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Several studies have reported an association between the genetic
variant rs738409 (G) in the PNPLA3 gene and the risk of cirrhosis in various liver diseases …

PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence

E Falleti, C Fabris, S Cmet, A Cussigh… - Liver …, 2011 - Wiley Online Library
Background and aim: The PNPLA3 rs738409 C> G polymorphism has been found to be
strongly associated with non‐alcoholic fatty liver disease and with alcoholic liver disease …

PNPLA3 gene polymorphism and liver-and extrahepatic cancer–related mortality in the United States

K Wijarnpreecha, M Scribani, P Raymond… - Clinical …, 2021 - cghjournal.org
Results Prevalence of genotypes CC, CG, and GG was 50.7%, 36.7%, and 12.6% among
4814 participants, whereas that of genotypes CC, CG, and GG in NAFLD was 45.3%, 38.6 …

Carriage of the PNPLA3 rs738409 C> G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

YL Liu, GL Patman, JBS Leathart, AC Piguet… - Journal of …, 2014 - Elsevier
Background & Aims Subtle inter-patient genetic variation and environmental factors combine
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …

[HTML][HTML] PNPLA3 as a genetic determinant of risk for and severity of non-alcoholic fatty liver disease spectrum

H Salameh, M Al Hanayneh, M Masadeh… - Journal of clinical and …, 2016 - ncbi.nlm.nih.gov
Abstract Background and Aims: Patatin-like phospholipase domain protein 3 (PNPLA3)
polymorphisms (rs738409 C> G) are associated with non-alcoholic fatty liver disease …

[PDF][PDF] Association of PNPLA3 polymorphism with hepatocellular carcinoma development and prognosis in viral and non-viral chronic liver diseases

A Khlaiphuengsin, R Kiatbumrung… - Asian Pac J Cancer …, 2015 - researchgate.net
Background: The aim of this study was to evaluate any association between a single
nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 …