High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis

M Hashizume, N Koike, H Yoshida, M Suzuki… - Modern …, 2010 - Taylor & Francis
We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the
progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model …

Effects of hyaluronic acid on cartilage degradation

D Uebelhart, JM Williams - Current Opinion in Rheumatology, 1999 - journals.lww.com
Based on the published literature available so far, it appears that naturally derived
hyaluronic acid (HA) and newer formulations available on the market belong to the …

The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid.

P Ghosh - Clinical and experimental rheumatology, 1994 - europepmc.org
Intra-articular administration of hyaluronic acid (Hyaluronan)(HA) is now gaining widespread
acceptance for the treatment of osteoarthritis (OA), even though little is known of its …

Effect of high molecular weight hyaluronan on cartilage degeneration in a rabbit model of osteoarthritis

T Kikuchi, H Yamada, M Shimmei - Osteoarthritis and cartilage, 1996 - Elsevier
The effects of high molecular weight hyaluronan (HA) on cartilage degeneration were
investigated in a partial menisectomy model of osteoarthritis (OA) in the rabbit knee. This …

Anti-inflammatory effects of hyaluronan in arthritis therapy: Not just for viscosity

K Masuko, M Murata, K Yudoh, T Kato… - International journal of …, 2009 - Taylor & Francis
Hyaluronic acid (HA) has been widely used for viscosupplementation of diseased or aged
articular joints. However, recent investigations have revealed the active anti-inflammatory or …

[HTML][HTML] Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action

LW Moreland - Arthritis Res Ther, 2003 - Springer
Although the predominant mechanism of intra-articular hyaluronan (hyaluronic acid)(HA)
and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in …

The disease-modifying effects of hyaluronan in the osteoarthritic disease state

MA Nicholls, A Fierlinger, F Niazi… - … Insights: Arthritis and …, 2017 - journals.sagepub.com
Hyaluronic acid (HA) has been a treatment modality for patients with knee osteoarthritis (OA)
for many years now. Since HA was first introduced for the treatment of painful knee OA …

Beneficial actions of hyaluronan (HA) on arthritic joints: effects of molecular weight of HA on elasticity of cartilage matrix

Y Kato, S Nakamura, M Nishimura - Biorheology, 2006 - content.iospress.com
Hyaluronan (HA) has viscoelastic, anti-inflammatory and protective actions in joint tissues,
and is being widely used for treatment of OA and RA patients. However, the mechanisms …

[HTML][HTML] Different effects of high molecular weight sodium hyaluronate and NSAID on the progression of the cartilage degeneration in rabbit OA model

M Mihara, S Higo, Y Uchiyama, K Tanabe… - Osteoarthritis and …, 2007 - Elsevier
OBJECTIVE: We examined the effects of nonsteroidal anti-inflammatory drug (NSAID) and
intra-articular injections of sodium hyaluronate (HA) on cartilage degeneration in rabbit knee …

[HTML][HTML] Hyaluronan does not affect cytokine and chemokine expression in osteoarthritic chondrocytes and synoviocytes

G Lisignoli, F Grassi, A Piacentini, B Cocchini… - Osteoarthritis and …, 2001 - Elsevier
Objective Many studies have evidenced the clinical efficacy of hyaluronan (HA) in the
treatment of osteoarthritis (OA). However, human and animal studies have described …