Despite a relatively high heritability, the search for obesity-susceptibility genes has been
challenging. While over the past 15 years, candidate gene studies and genome-wide …

During the past several decades, there has been an explosion in the prevalence of obesity.
Since our genes have not changed appreciably during that time, it stands to reason that the …

Tremendous progress has been made in the genetic elucidation of obesity over the past two
decades, driven largely by technological, methodological and organizational innovations …

Gene–environment interactions are central to the expression of obesity. The condition is
strongly heritable (ie, genetic), and most of the variation in obesity levels between countries …

Obesity is a major public health problem with a significant genetic component. Multiple DNA
polymorphisms/genes have been shown to be strongly associated with obesity, typically in …

Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …

The genetic contribution to interindividual variation in common obesity has been estimated
at 40–70%. Yet, despite a relatively high heritability, the search for obesity susceptibility …

All definitions of the metabolic syndrome include some form of obesity as one of the possible
features. Body mass index (BMI) has a known genetic component, currently estimated to …

Genome-wide association promises to enhance greatly our understanding of the genetic
basis of common obesity, although candidate gene studies will remain a valuable approach …

Obesity is a major public health problem with strong genetic determination. Multiple genetic
variants have been implicated for obesity by conducting genome-wide association (GWA) …