Activator of metastasis in cancer cells, Mst1/S100A4 protein binds to tumor suppressor protein p53

M Grigorian, E Lukanidin - Genetika, 2003 - europepmc.org
This study for the first time demonstrates a physical and functional interaction between the
Ca (2+)-binding protein Mts1/S100A4 and tumor suppressor p53 protein. Using different in …

[HTML][HTML] Heterocomplex formation between metastasis-related protein S100A4 (Mts1) and S100A1 as revealed by the yeast two-hybrid system

S Tarabykina, M Kriajevska, DJ Scott, TJ Hill, D Lafitte… - FEBS letters, 2000 - Elsevier
S100A4 (Mts1) is a Ca2+-binding protein of the S100 family. This protein plays an important
role in promoting tumor metastasis. In order to identify S100A4 interacting proteins, we have …

Key promoter elements involved in transcriptional activation of the cancer-related gene coding for S100P calcium-binding protein

A Gibadulinova, I Oveckova, S Parkkila… - Oncology …, 2008 - spandidos-publications.com
S100P gene encodes a calcium-binding protein expressed in different tumor tissues and is
functionally implicated in malignant phenotype. Despite consistent relationship to cancer …

Tissue-Specific Posttranscriptional Downregulation of Expression of the S100A4(mts1) Gene in Transgenic Animals

N Ambartsumian, J Klingelhöfer, M Grigorian… - Invasion and …, 1999 - karger.com
Abstract The S100A4 (mts1) is a gene associated with generation of metastatic disease. In
order to analyze the consequences of alteration of the pattern of expression of the S100A4 …

Induction of 18A2/mts1 Gene Expression and Its Effects on Metastasis and Cell Cycle Control

C Parker, PA Whittaker, BA Usmani… - DNA and cell …, 1994 - liebertpub.com
The metastasis associated 18A2/mts1 gene was inserted into the mammalian expression
vector pMAM neo placing it under the control of the dexamethasone-inducible MMTV …

[HTML][HTML] Binding of two nuclear complexes to a novel regulatory element within the human S100A9 promoter drives the S100A9 gene expression

C Kerkhoff, HA Hofmann, J Vormoor… - Journal of Biological …, 2002 - ASBMB
S100A9, also referred to as MRP14, is a calcium-binding protein whose expression is tightly
regulated during differentiation of myeloid cells. The present study was performed to study …

The metastasis-associated Mts1 (S100A4) protein could act as an angiogenic factor

N Ambartsumian, JÈ KlingelhoÈfer, M Grigorian… - Oncogene, 2001 - nature.com
The involvement of Mts1 (S100A4), a small Ca 2+-binding protein in tumor progression and
metastasis had been demonstrated. However, the mechanism by which mts1 (S100A4) …

[HTML][HTML] A κB-related binding site is an integral part of the mts1 gene composite enhancer element located in the first intron of the gene

E Tulchinsky, E Prokhortchouk, G Georgiev… - Journal of Biological …, 1997 - ASBMB
The transcription of the mts1 gene correlates with the metastatic potential of mouse
adenocarcinomas. Here we describe strong enhancer whose location coincides with the …

Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung …

K Takenaga, Y Nakamura, S Sakiyama - Oncogene, 1997 - nature.com
S100A4 (also known as pEL98/mts1/p9Ka/18A2/42A/calvasculin/FSP1/CAPL), a member of
S100-related calcium-binding proteins, has been implicated to play a role in metastasis. In …

Metastasis-Related mts 1 Gene

EM Lukanidin, GP Georgiev - Attempts to Understand Metastasis …, 1996 - Springer
Metastasis is a multistep process involving detachment of cells from the primary tumor,
invasion and penetration of the basement membranes of blood vessels, survival in the blood …