Molecular and genetic profiling for precision medicines in pulmonary arterial hypertension
S Fazal, M Bisserier, L Hadri - Cells, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a rare and chronic lung disease characterized by
progressive occlusion of the small pulmonary arteries, which is associated with structural …
progressive occlusion of the small pulmonary arteries, which is associated with structural …
[HTML][HTML] Pulmonary arterial hypertension: Emerging principles of precision medicine across basic science to clinical practice
NJ Kelly, SY Chan - Reviews in cardiovascular medicine, 2022 - ncbi.nlm.nih.gov
Pulmonary arterial hypertension (PAH) is an enigmatic and deadly vascular disease with no
known cure. Recent years have seen rapid advances in our understanding of the molecular …
known cure. Recent years have seen rapid advances in our understanding of the molecular …
Molecular genetic framework underlying pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder typified by occlusion
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …
Targeting vascular remodeling to treat pulmonary arterial hypertension
AAR Thompson, A Lawrie - Trends in molecular medicine, 2017 - cell.com
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …
[HTML][HTML] Pulmonary arterial hypertension: Cellular and molecular changes in the lung
BA Maron - Global Cardiology Science & Practice, 2020 - ncbi.nlm.nih.gov
The range of cell types identified in the pathogenesis of pulmonary arterial hypertension
(PAH) has expanded substantially since the first pathological descriptions of this disease …
(PAH) has expanded substantially since the first pathological descriptions of this disease …
Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension
MW Gorr, K Sriram, A Muthusamy… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose Pulmonary arterial hypertension (PAH, type 1 pulmonary
hypertension) has a 3‐year survival of~ 50% and is in need of new, effective therapies. In …
hypertension) has a 3‐year survival of~ 50% and is in need of new, effective therapies. In …
Epigenetic regulation of pulmonary arterial hypertension-induced vascular and right ventricular remodeling: new opportunities?
JMM Kocken, PA da Costa Martins - International journal of molecular …, 2020 - mdpi.com
Pulmonary artery hypertension (PAH) is a rare chronic disease with high impact on patients'
quality of life and currently no available cure. PAH is characterized by constant remodeling …
quality of life and currently no available cure. PAH is characterized by constant remodeling …
Translational Advances in the Field of Pulmonary Hypertension.Focusing on Developmental Origins and Disease Inception for the Prevention of Pulmonary …
Persistent challenges in managing pulmonary vascular disease progression and poor
outcomes, despite the aggressive use of current drug therapies, highlight the need for …
outcomes, despite the aggressive use of current drug therapies, highlight the need for …
New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication
Pulmonary arterial hypertension (PAH) is a disorder in which mechanical obstruction of the
pulmonary vascular bed is largely responsible for the rise in mean pulmonary arterial …
pulmonary vascular bed is largely responsible for the rise in mean pulmonary arterial …
Clarifying the pulmonary arterial hypertension molecular landscape using functional genetics
BA Maron - American Journal of Respiratory and Critical Care …, 2020 - atsjournals.org
Pulmonary arterial hypertension (PAH) is a complex cardiopulmonary disease that is
associated with numerous pathogenetic molecular mechanisms and results in mixed …
associated with numerous pathogenetic molecular mechanisms and results in mixed …