Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond

C Weber, AJR Habenicht… - European heart …, 2023 - academic.oup.com
This review based on the ESC William Harvey Lecture in Basic Science 2022 highlights
recent experimental and translational progress on the therapeutic targeting of the …

Evolving concepts in the triad of atherosclerosis, inflammation and thrombosis

R Corti, R Hutter, JJ Badimon, V Fuster - Journal of thrombosis and …, 2004 - Springer
Recent developments into antherothrombosis, the leading cause of morbidity and mortality
in Western Society, may help to change our treatment strategy to a more casual approach …

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of …

DFJ Ketelhuth, E Lutgens, M Bäck… - Cardiovascular …, 2019 - academic.oup.com
Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the
Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the …

[HTML][HTML] Thematic review series: The immune system and atherogenesis. Cytokines affecting endothelial and smooth muscle cells in vascular disease

EW Raines, N Ferri - Journal of lipid research, 2005 - ASBMB
The cellular and extracellular matrix accumulations that comprise the lesions of
atherosclerosis are driven by local release of cytokines at sites of predilection for lesion …

Invited review: Vascular cells contribute to atherosclerosis by cytokine-and innate-immunity-related inflammatory mechanisms

H Loppnow, K Werdan, M Buerke - Innate immunity, 2008 - journals.sagepub.com
Cardiovascular diseases are the human diseases with the highest death rate and
atherosclerosis is one of the major underlying causes of cardiovascular diseases …

Inflammation and cardiac outcome

PJ Hohensinner, A Niessner, K Huber… - Current opinion in …, 2011 - journals.lww.com
Inflammation and cardiac outcome : Current Opinion in Infectious Diseases Inflammation
and cardiac outcome : Current Opinion in Infectious Diseases Log in or Register Subscribe …

Inflammatory biomarkers and coronary heart disease: from bench to bedside and back

G Biasillo, M Leo, R Della Bona… - Internal and emergency …, 2010 - Springer
Inflammation plays a pivotal role in all stages of atherosclerosis from endothelial dysfunction
and plaque formation to plaque destabilization and disruption. Inflammatory biomarkers …

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

P Raggi, J Genest, JT Giles, KJ Rayner, G Dwivedi… - Atherosclerosis, 2018 - Elsevier
Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …

Targeting inflammation in CVD: advances and challenges

KJ Moore - Nature Reviews Cardiology, 2019 - nature.com
Considerable evidence supports a role for low-grade chronic inflammation in the
atherothrombotic process, from plaque initiation to acute plaque rupture preceding …

Atherosclerosis and innate immune signaling

MA Laberge, KJ Moore, MW Freeman - Annals of medicine, 2005 - Taylor & Francis
Atherosclerosis, the leading cause of death in developed countries, is characterized by
chronic inflammation in the artery wall. It has been appreciated for decades that this disease …