Early in the course of psychosis, alterations in brain connectivity accompany the emergence
of psychiatric symptoms and cognitive impairments, including processing speed. The clinical …

The early stage of psychosis (ESP) is a critical period where effective intervention has the
most favorable impact on outcomes. Thalamic connectivity abnormalities have been …

Connectomic approaches using diffusion tensor imaging have contributed to our
understanding of brain changes in psychosis, and could provide further insights into the …

Neuroimaging studies have identified patterns of brain abnormalities in various stages of
schizophrenia, but whether these abnormalities reflect primary factors associated with the …

Importance Brain imaging studies have identified robust changes in brain structure and
function during the development of psychosis, but the contribution of abnormal brain …

Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been
associated with cortico-striatal dysfunction. This work has largely relied on a discrete …

Background Schizophrenia, a neurodevelopmental disorder, involves abnormalities in
functional connectivity (FC) across distributed neural networks, which are thought to …

Brain changes in schizophrenia evolve along a dynamic trajectory, emerging before disease
onset and proceeding with ongoing illness. Recent investigations have focused attention on …

Analyzing the schizophrenia connectome can identify illness-related alterations in
connectivity across the brain. An important question that remains unanswered is whether …

Background Machine learning (ML) can distinguish cases with psychotic disorder from
healthy controls based on magnetic resonance imaging (MRI) data, but it is not yet clear …