The first structural analysis comparing the binding mode to the target carbonic anhydrases
(CAs, EC 4.2. 1.1) of two opposite classes of modulators is presented here: coumarin …

The inhibition of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) with three
phenols was investigated. Phenol was an effective CA I–IV, IX, XII and XIV inhibitor (KIs of …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are inhibited by sulfonamides, inorganic anions,
phenols, coumarins (acting as prodrugs) and polyamines. A novel class of CA inhibitors …

Coumarin derivatives are a peculiar class of inhibitors of the family of metalloenzymes
carbonic anhydrases (CA, EC 4.2. 1.1). Several coumarins display higher affinity and …

Coumarins constitute a general and totally new class of inhibitors of the zinc enzyme
carbonic anhydrase (CA, EC 4.2. 1.1), binding at the entrance of the active site cavity. We …

The X-ray crystal structure for the adduct of human carbonic anhydrase II (hCA II) with 4-(4-
sulfamoylphenylcarboxamidoethyl) benzenesulfonamide, a topically acting antiglaucoma …

Coumarins constitute a relatively new class of inhibitors of the zinc enzyme carbonic
anhydrase (CA, EC 4.2. 1.1), possessing a unique inhibition mechanism, acting as “prodrug …

(3-Tosylureido) pyridine-2-sulfonamide and 4-tosylureido-benzenesulfonamide (ts-SA) only
differ by the substitution of a CH by a nitrogen atom, but they have very different inhibitory …

Coumarin derivatives were recently shown to constitute a totally new class of inhibitors of the
zinc metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1), being hydrolyzed within the CA …

A series of coumarins and the corresponding 2-thioxocoumarines were prepared and tested
for their inhibition profiles against four physiologically relevant human carbonic anhydrases …