An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite

GYS Delgado, M Navarro - Coordination Chemistry Reviews, 2024 - Elsevier
Malaria is one of the oldest and deadliest parasitic diseases globally, and it still poses a
global health issue today because of the emergence of new strains resistant to the first-line …

Gold complexes as potential anti-parasitic agents

M Navarro - Coordination Chemistry Reviews, 2009 - Elsevier
The medical uses of gold have a long history; rheumatoid arthritis is currently treated with
gold-based drugs and there is increasing interest in the application of gold complexes as …

Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure

BĐ Glišić, MI Djuran - Dalton Transactions, 2014 - pubs.rsc.org
Interest in antimicrobial gold complexes originated from the work of Robert Koch at the end
of 19th century, who demonstrated that potassium dicyanidoaurate (I), K [Au (CN) 2], showed …

[HTML][HTML] Hybrid gold (I) NHC-artemether complexes to target falciparum malaria parasites

M Ouji, G Barnoin, Á Fernández Álvarez, JM Augereau… - Molecules, 2020 - mdpi.com
The emergence of Plasmodium falciparum parasites, responsible for malaria disease,
resistant to antiplasmodial drugs including the artemisinins, represents a major threat to …

Gold(i) phosphine compounds as parasite attenuating agents for malaria vaccine and drug development

A Ssemaganda, LM Low, KR Verhoeft, M Wambuzi… - Metallomics, 2018 - academic.oup.com
Here, the anti-malarial activity of two gold (i) phosphine compounds auranofin and [Au
(d2pype) 2] Cl (where d2pype is 1, 2-bis (di-2-pyridylphosphino) ethane), were examined to …

[HTML][HTML] Gold (I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

K Fourmy, M Gouygou… - Comptes …, 2017 - comptes-rendus.academie-sciences …
A series of gold (I)-monophosphole complexes have been synthesized and characterized.
The introduction of a nitrogen moiety in the complex structure was envisioned either by …

Antiplasmodial activities of gold (I) complexes involving functionalized N-heterocyclic carbenes

C Hemmert, AP Ramadani, L Boselli, AF Alvarez… - Bioorganic & medicinal …, 2016 - Elsevier
A series of twenty five molecules, including imidazolium salts functionalized by N-, O-or S-
containing groups and their corresponding cationic, neutral or anionic gold (I) complexes …

[HTML][HTML] Biological activity of gold compounds against viruses and parasitosis: a systematic review

C Fonseca, M Aureliano - BioChem, 2022 - mdpi.com
In this contribution, we provide an overview of gold compound applications against viruses
or parasites during recent years. The special properties of gold have been the subject of …

A “Golden Age” for the discovery of new antileishmanial agents: current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione …

LB Rosa, RL Aires, LS Oliveira, JV Fontes… - …, 2021 - Wiley Online Library
Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious
public health issue. The current therapeutic options have several disadvantages that make …

Therapeutic gold compounds

SJ Berners‐Price, PJ Barnard - Ligand Design in Medicinal …, 2014 - Wiley Online Library
Whilst the application of gold in medicine is traceable for several thousand years and gold
drugs have been used clinically to treat rheumatoid arthritis since the last century, there has …