Antibiotics: A “GOLDen” promise?

CI Yeo, CHP Goh, ERT Tiekink, J Chew - Coordination Chemistry Reviews, 2024 - Elsevier
Bacterial infections pose a significant threat to public health and the global economy. The
misuse of antibiotics in the treatment of bacterial infections has led to a rapid development of …

Gold: not just jewelry…

F Brescia, L Ronconi - Future Medicinal Chemistry, 2023 - Taylor & Francis
Plain language summary From jewels and coinage to anticancer and antiviral agents, the
peculiar 'soft'character as well as physicochemical, redox and ligand exchange properties of …

Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials

C Gabbiani, L Messori, MA Cinellu, A Casini… - Journal of inorganic …, 2009 - Elsevier
A variegate group of metallodrugs was evaluated in vitro for antimalarial activity through the
pLDH test. The panel comprised one mononuclear gold (III) complex,(Aubipy), three …

Potency of copper (II) complexes towards drug-sensitive and-resistant Plasmodium falciparum: Structure-activity relationship, ROS-generation and proteasome …

JW Lai, MJ Maah, R Sarip, YAL Lim, KL Tim… - Journal of Molecular …, 2022 - Elsevier
The use of copper in medicine has a long history and copper-containing compounds have
multiple applications, such as in treating heart disease, arthritis, cancer, parasitic as well as …

Antimalarial Agents Derived from Metal‐Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle

L Colina‐Vegas, M da Cruz B. Silva… - … A European Journal, 2023 - Wiley Online Library
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are
excellent ligands for metal coordination and are deployed as drugs for malaria treatment …

Gold Drugs with {Au(PPh3)}+ Moiety: Advantages and Medicinal Applications

JR Stenger‐Smith, PK Mascharak - ChemMedChem, 2020 - Wiley Online Library
Following the success of Auranofin as an anti‐arthritic drug, search for novel gold drugs has
afforded a large number of [L− Au (PPh3)] complexes that exhibit notable salutary effects …

Molecular mechanisms and clinical implications of the gold drug auranofin

S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Gold complexes for therapeutic purposes: an updated patent review (2010-2015)

C Nardon, N Pettenuzzo… - Current Medicinal …, 2016 - ingentaconnect.com
Gold has always aroused great interest in the history of mankind. It has been used for
thousands of years for jewelry, religious cult valuables, durable goods and in the art world …

Design, Synthesis and Efficacy of Hybrid Triclosan‐gold Based Molecules on Artemisinin‐resistant Plasmodium falciparum and Leishmania infantum Parasites

M Ouji, SB Delmas, ÁF Álvarez, JM Augereau… - …, 2020 - Wiley Online Library
The emergence of resistant parasites, Plasmodium and Leishmania, responsible of malaria
and leishmaniasis diseases, to the currently available drugs, remains one of the major …