Toward a novel metal-based chemotherapy against tropical diseases. 7. Synthesis and in vitro antimalarial activity of new gold− chloroquine complexes

M Navarro, F Vasquez… - Journal of Medicinal …, 2004 - ACS Publications
A number of new Au (I) and Au (III) complexes of chloroquine (CQ) have been prepared,
characterized, and evaluated in vitro against several strains of Plasmodium falciparum.[(CQ) …

[PDF][PDF] Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes

G Colotti, A Ilari, A Fiorillo, P Baiocco, MA Cinellu… - …, 2013 - academia.edu
Leishmaniasis is a set of severe parasitic diseases for which only a limited number of
effective drugs are available, including two antimony-based agents (sodium stibogluconate …

Transition Metal Complexes as Antimalarial Agents: A Review

A Mandal, R Kushwaha, AA Mandal, S Bajpai… - …, 2023 - Wiley Online Library
In antimalarial drug development research, overcoming drug resistance has been a major
challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine …

Stability and reactivity of gold compounds–From fundamental aspects to applications

MD Đurović, ŽD Bugarčić, R van Eldik - Coordination Chemistry Reviews, 2017 - Elsevier
This review summarizes the chemistry of gold (0/I/II/III) compounds and outlines progress
made towards obtaining more stable coordination compounds in order to improve their …

Synthesis and characterization of a pyridine-2-thiol N-oxide gold (I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight …

M Vieites, P Smircich, L Guggeri, E Marchán… - Journal of inorganic …, 2009 - Elsevier
In the search for new therapeutic tools against parasitic diseases caused by the
Kinetoplastids Leishmania spp. and Trypanosoma cruzi, a novel gold (I) triphenylphosphine …

Synthesis, structures, and antimalarial activities of some silver (I), gold (I) and gold (III) complexes involving N-heterocyclic carbene ligands

C Hemmert, A Fabié, A Fabre, F Benoit-Vical… - European journal of …, 2013 - Elsevier
A series of mono-and dinuclear silver (I) and mononuclear gold (I) complexes containing bis
(N-heterocyclic carbene)(NHC) or N-functionalized NHC ligands were synthesized and fully …

Chemical modification of Auranofin yields a new family of anticancer drug candidates: the gold (I) phosphite analogues

D Cirri, A Geri, L Massai, M Mannelli, T Gamberi… - Molecules, 2023 - mdpi.com
A panel of four novel gold (I) complexes, inspired by the clinically established gold drug
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …

The Golden Future in Medicinal Chemistry: Perspectives and Resources From Old and New Gold-Based Drug Candidates

L Massai, S Grguric-Sipka, W Liu, B Bertrand… - Frontiers in …, 2021 - frontiersin.org
Gold compounds started to play an important role in modern medicine after the discovery of
the efficacy of some gold salts against tuberculosis strains by Robert Koch (Sigel et al …

Structure–activity relationship of anticancer and antiplasmodial gold bis (dithiolene) complexes

C Vitré, Y Le Gal, A Vacher, T Roisnel, D Lorcy… - Dalton …, 2024 - pubs.rsc.org
Monoanionic gold bis (dithiolene) complexes were recently shown to display activity against
ovarian cancer cells, Gram-positive bacteria, Candida strains and the rodent malaria …

Gold complexes with benzimidazole derivatives: synthesis, characterization and biological studies

VZ Mota, GSG de Carvalho, AD da Silva, LAS Costa… - Biometals, 2014 - Springer
Synthesis, characterization, DFT studies and biological assays of new gold (I) and gold (III)
complexes of benzimidazole are reported. Molecular and structural characterizations of the …