Bioinorganic applications of gold and platinum coordination compounds: a brief historical overview and recent advances in 2017

REF de Paiva, PP Corbi - International Journal of Advances in …, 2018 - journalamb.com
Gold-based metallodrugs have been used for a wide variety of medical–related applications.
Although none of them have reached clinical trials, many compounds show potential for a …

Chemical biology of anticancer gold (III) and gold (I) complexes

T Zou, CT Lum, CN Lok, JJ Zhang… - Chemical Society Reviews, 2015 - pubs.rsc.org
Gold complexes have recently gained increasing attention in the design of new metal-based
anticancer therapeutics. Gold (III) complexes are generally reactive/unstable under …

Metal complexes as chemotherapeutic agents against tropical diseases: trypanosomiasis, malaria and leishmaniasis

RA Sánchez-Delgado… - Mini reviews in medicinal …, 2004 - ingentaconnect.com
Parasitic diseases represent a major world health problem with very limited therapeutic
options, most of the available treatments being decades old and suffering from limited …

Heteroleptic (S^ C)-cyclometallated gold (III) complexes as novel antiviral agents

M Balsera-Manzanero, RG Soengas… - Heliyon, 2024 - cell.com
Despite the increasingly widespread clinical impact of adenovirus (HAdV) infections in
healthy individuals and the associated high morbidity in immunosuppressed patients …

Medicinal Au (I) compounds targeting urease as prospective antimicrobial agents: Unveiling the structural basis for enzyme inhibition

L Mazzei, L Massai, M Cianci, L Messori, S Ciurli - Dalton Transactions, 2021 - pubs.rsc.org
A few gold compounds were recently found to show antimicrobial properties in vitro, holding
great promise for the discovery of new drugs to overcome antibiotic resistance. Here, the …

Advances in alkynyl gold complexes for use as potential anticancer agents

Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …

Organometallic Gold(III) Complex [Au(Hdamp)(L14)]+ (L1 = SNS-Donating Thiosemicarbazone) as a Candidate to New Formulations against Chagas Disease

CD Lopes, B Possato, APS Gaspari… - ACS Infectious …, 2019 - ACS Publications
Chagas disease remains a serious public health concern with unsatisfactory treatment
outcomes due to strain-specific drug resistance and various side effects. To identify new …

Gold(I) ion and the phosphine ligand are necessary for the anti-Toxoplasma gondii activity of auranofin

CI Ma, JA Tirtorahardjo, SS Schweizer… - Microbiology …, 2024 - Am Soc Microbiol
Auranofin, an FDA-approved drug for rheumatoid arthritis, has emerged as a promising
antiparasitic medication in recent years. The gold (I) ion in auranofin is postulated to be …

Gold and its complexes in anticancer chemotherapy

MY Wani, MA Malik, OJM Islamia - 2021 - Springer
Among the different types of human diseases known, cancer is the most dreadful and
challenging disease. It is the second leading cause of death globally, accounting for an …

Gold (III) complexes in the oncological preclinical arena: from aminoderivatives to peptidomimetics

C Nardon, D Fregona - Current topics in medicinal chemistry, 2016 - ingentaconnect.com
In the last decade, we have been developing some gold (III) derivatives showing interesting
antitumor properties and reduced systemic and renal toxicity, compared to the clinically …