Value of combining biological age with assessment of individual frailty to optimize management of cancer treated with targeted therapies: model of chronic myeloid …

M Casile, G Albrand, B Lebecque, J Besombes… - BMC cancer, 2024 - Springer
Background In the era of targeted therapies, the influence of aging on cancer management
varies from one patient to another. Assessing individual frailty using geriatric tools has its …

Hematological Cancer in Older Adults with Frailty

V Goede - Frailty in Older Adults with Cancer, 2022 - Springer
The majority of hematological cancers are age-associated diseases. Therefore, many
patients with hematological malignancies are older and may present with frailty, ie the loss …

A randomized clinical study on the impact of Comprehensive Geriatric Assessment (CGA) based interventions on the quality of life of elderly, frail, onco-hematologic …

AM Mahmoud, F Biello, PM Maggiora, R Bruna… - BMC geriatrics, 2021 - Springer
Background Age is considered as one of the most important risk-factor for many types of
solid and hematological cancers, as their incidence increases with age in parallel to the ever …

The relevance of a geriatric assessment for elderly patients with a haematological malignancy–a systematic review

ME Hamaker, MC Prins, R Stauder - Leukemia research, 2014 - Elsevier
Background Geriatric assessment is increasingly used to assess the health status of older
cancer patients. We set out to assemble all available evidence on the relevance of a …

First-line treatment of newly diagnosed elderly patients with chronic myeloid leukemia: current and emerging strategies

G Gugliotta, F Castagnetti, M Apolinari, S Pirondi… - Drugs, 2014 - Springer
Chronic myeloid leukemia (CML) is a disease of the hematopoietic stem cell characterized
by a median age at diagnosis of 60–65 years according to most epidemiologic registries …

Tyrosine kinase inhibitors for elderly chronic myeloid leukemia patients: a systematic review of efficacy and safety data

M Breccia, M Tiribelli, G Alimena - Critical reviews in oncology/hematology, 2012 - Elsevier
The impact of age as a poor prognostic factor in chronic myeloid leukemia (CML) has been
well described. In the interferon era, elderly patients diagnosed as having chronic phase …

Engineering the fitness of older patients for chemotherapy: An exploration of Comprehensive Geriatric Assessment in practice

AL McCarthy, PS Cook, P Yates - Health:, 2014 - journals.sagepub.com
Clinicians often report that currently available methods to assess older patients, including
standard clinical consultations, do not elicit the information necessary to make an …

Treatment of chronic myeloid leukemia elderly patients in the tyrosine kinase inhibitor era

D Russo, M Malagola, C Skert, C Filì… - Current Cancer Drug …, 2013 - ingentaconnect.com
The prevalence of chronic myeloid leukemia (CML) is expected to double in the next 15
years. The introduction of imatinib significantly changed the prognosis of CML, challenging …

[HTML][HTML] Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate, toxicity and outcome

A Iurlo, A Nobili, R Latagliata, C Bucelli, F Castagnetti… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Background About 40% of all patients with chronic myeloid leukemia are currently old or
very old. They are effectively treated with imatinib, even though underrepresented in clinical …

Cancer and aging: two tightly interconnected biological processes

L Berben, G Floris, H Wildiers, S Hatse - Cancers, 2021 - mdpi.com
Simple Summary As life expectancy is increasing, the older population is rapidly growing.
However, older patients with cancer are still underrepresented in clinical trials, making …