Ribosome inhibiting proteins, RIPs, are a widespread family of toxic enzymes. Ricin is a
plant toxin used as a poison and biological warfare agent; shiga toxin is a homologue …

Ricin is a potent cytotoxin easily purified in large quantities. It presents a significant public
health concern due to its potential use as a bioterrorism agent. For this reason, extensive …

We used two virtual screening programs, ICM and GOLD, to dock nearly 50,000 compounds
into each of two conformations of the target protein ricin A chain (RTA). A limited control set …

Ricin is a potent heterodimeric cytotoxin; the B chain binds eucaryotic cell surfaces aiding
uptake and the A chain, RTA, reaches the cytoplasm where it enzymatically depurinates a …

Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and
depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting …

The Category B agents, ricin and shiga toxin (Stx), are RNA N-glycosidases that target a
highly conserved adenine residue within the sarcin-ricin loop of eukaryotic 28S ribosomal …

Ricin, a category-B agent for bioterrorism, and Shiga toxins (Stxs), which cause food
poisoning bind to the ribosomal P-stalk to depurinate the sarcin/ricin loop. No effective …

Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a
specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical …

Ricin is a potent cytotoxin with experimental and clinical uses; it has also been used as a
poison. There is considerable interest in identifying or designing inhibitors of the toxin that …

Ricin produced by the castor bean plant and Shiga toxins produced by pathogenic
Escherichia coli (STEC) and Shigella dysenteriae are type II ribosome inactivating proteins …