Quantification of DNA Lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in mammalian cells
Quantitative measurement of DNA adducts in carcinogen-exposed cells provides the
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA
P Upadhyaya, SJ Sturla, N Tretyakova… - Chemical research in …, 2003 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of the tobacco specific
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
Liquid chromatography-tandem mass spectrometry for the quantification of tobacco-specific nitrosamine-induced DNA adducts in mammalian cells
Quantification of DNA lesions constitutes one of the main tasks in toxicology and in
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines
L Li, J Perdigao, AE Pegg, Y Lao… - Chemical research in …, 2009 - ACS Publications
Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-
nitrosonornicotine, are considered to be human carcinogens. Both compounds are …
nitrosonornicotine, are considered to be human carcinogens. Both compounds are …
Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N …
SS Hecht, TE Spratt, N Trushin - Carcinogenesis, 1988 - academic.oup.com
DNA was isolated from tissues of K344 rats 24 h after treatment by sc injection with [5-3 H] 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone ([5-3 H] NNK) or [5-3 H] N′-nitrosonor …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone ([5-3 H] NNK) or [5-3 H] N′-nitrosonor …
In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
LA Peterson, R Mathew, SE Murphy, N Trushin… - …, 1991 - academic.oup.com
The persistence of pyridyloxobutyl DNA adducts in lung and liver of F-344 rats treated with
the tobacco-specific nitrosamine 4-(methybiitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was …
the tobacco-specific nitrosamine 4-(methybiitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was …
Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific …
SJ Sturla, J Scott, Y Lao, SS Hecht… - Chemical research in …, 2005 - ACS Publications
Exposure to the tobacco-related nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and N '-nitrosonornicotine is carcinogenic to humans. Metabolic activation …
butanone (NNK) and N '-nitrosonornicotine is carcinogenic to humans. Metabolic activation …
Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage
JF Cloutier, A Castonguay - Chemico-biological interactions, 1998 - Elsevier
The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is
present in tobacco smoke and is hepatocarcinogenic in rats. Its bioactivation in rat …
present in tobacco smoke and is hepatocarcinogenic in rats. Its bioactivation in rat …
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated …
M Wang, G Cheng, SJ Sturla, Y Shi… - Chemical research in …, 2003 - ACS Publications
The tobacco specific carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl …
ME Staretz, PG Foiles, LM Miglietta, SS Hecht - Cancer research, 1997 - AACR
Abstract The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK), selectively induces lung tumors in F344 rats. NNK is metabolically activated to …
(NNK), selectively induces lung tumors in F344 rats. NNK is metabolically activated to …