Human CD81, a known receptor for hepatitis C virus envelope E2 glycoprotein, is a
transmembrane protein belonging to the tetraspanin family. The crystal structure of human …

Tetraspanins are a superfamily of transmembrane proteins implicated in cellular
development, motility, and activation through their interactions with a large range of proteins …

The tetraspanin web is composed of a network of tetraspanins and their partner proteins that
facilitate cellular interactions and fusion events by an unknown mechanism. Our aim was to …

By associating with specific partner molecules and with each other, the tetraspanins are
thought to assemble multimolecular complexes that may be especially relevant with respect …

The CD81 tetraspanin was first identified as a hepatitis C virus (HCV) receptor by its ability to
bind the soluble ectodomain of envelope glycoprotein E2 (sE2). More recently, it has been …

As the human tetraspanin CD81 binds hepatitis C virus (HCV) envelope glycoprotein E2, we
addressed the role CD81 may play in cellular trafficking of HCV envelope proteins. Studies …

CD81 is a tetraspanin protein that is involved in several essential cellular functions, as well
as in the hepatitis C virus (HCV) infection. CD81 interacts with a high stoichiometry with its …

ABSTRACT A truncated soluble form of the hepatitis C virus E2 glycoprotein, E2661, binds
specifically to the surface of cells expressing human CD81 (hCD81) but not other members …

The tetraspanin family of membrane glycoproteins is involved in the regulation of cellular
development, proliferation, activation, and mobility. We have attempted to predict the …

Several tetraspanins bind directly to a few molecular partners to form primary complexes,
which might assemble through tetraspanin–tetraspanin interactions to form a network of …