Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

Our conception of programmed cell death has expanded beyond apoptosis to encompass
additional forms of cell suicide, including necroptosis and pyroptosis; these cell death …

Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has
achieved considerable success in the clinic. However, ICIs are significantly limited by the …

Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment,
with notable therapeutic effects on certain cancer types. Despite their significant potential …

The host immune system is continuously exposed to dying cells and has evolved to
distinguish between cell death events signaling potential threats and physiological …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

The immune system is routinely exposed to dead cells during normal cell turnover, injury
and infection. Mechanisms must exist to discriminate between different forms of cell death to …