Identifying key genes that regulate the complex diseases of the cardiovascular system can
be greatly facilitated with the use of microarrays. In an effort to obtain a global portrait of …

Our understanding of the cardiovascular system has evolved through the years by extensive
studies emphasizing the identification of the molecular and physiological mechanisms …

Cardiovascular disease is the most important cause of morbidity and mortality in developed
countries, causing twice as many deaths as cancer in the USA. The major cardiovascular …

Although the contribution of genetics to complex cardiovascular diseases such as
atherosclerosis has been accepted for quite some time, full and detailed knowledge of the …

With the emergence of microarray technology, it is now possible to simultaneously assess
the expression of tens of thousands of gene transcripts, providing a resolution and precision …

Genomics and proteomics are becoming powerful tools for profiling diseased states. The
human genome is estimated to encode 30,000 to 40,000 genes, generating more than …

Dramatic progress has been made in the technologies available to assess global alterations
in mRNA levels in both clinical and research samples. Through commercial services and …

Traditional gene expression studies typically focus on one or a few genes of interest. An
important limitation of single-gene studies is that they present a portrait of disease that is …

To obtain region-and disease-specific transcription profiles of human myocardial tissue, we
explored mRNA expression from all four chambers of eight explanted failing [idiopathic …

The number of cardiovascular publications featuring gene expression profiling technologies
is growing rapidly. This article introduces four profiling techniques; serial analysis of gene …