Endothelial integrity is dependent on intracellular adherens junctions formed by complexes
of vascular endothelial (VE)-cadherin and catenins. We have previously demonstrated that …

Abstract Background Slug, Snail, and Twist are transcription factors that regulate the
expression of tumor suppressors such as E-cadherin. We examined the distribution and …

Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma
development and progression. Because previous data suggest that loss of E-cadherin …

Vascular endothelial-specific cadherin (VE-cadherin) is an endothelial cell-specific
adhesion molecule, localized at cell–cell contact sites. It is involved in physiological and …

Adherens junctions of the endothelium play a key role in the maintenance of endothelial
permeability and are composed of the vascular endothelial (VE)-cadherin/catenin adhesion …

Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of
normal and tumour vessels. In this report, we characterized the transcriptional activity of the …

E-cadherin protein plays a key role in the establishment and maintenance of adherent
junctions. Recent evidence implicates the transcription factor Snail in the blockage of E …

It has been suggested that down-regulation of E-cadherin in invasive breast ductal
carcinomas is mediated by the aberrant expression of several of its transcriptional …

Twist is a basic helix loop helix protein that plays a role both in development and in cancer
biogenesis. While characterizing the effects of Twist on breast epithelial cell transformation …

Data collected during the past years indicate that AJ-and more specifically VE-cadherin play
an important role in endothelial cell biology. VE-cadherin may transfer information …