A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi
The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary
metabolites by ascomycete fungi. However, little is known of its regulatory role in …
metabolites by ascomycete fungi. However, little is known of its regulatory role in …
Functions of reactive oxygen species in apoptosis and ganoderic acid biosynthesis in Ganoderma lucidum
J Zhu, F Wu, S Yue, C Chen, S Song… - FEMS Microbiology …, 2019 - academic.oup.com
Ganoderma lucidum is a medicinal fungus that is widely used in traditional medicine. Fungal
PacC is recognized as an important transcription factor that functions during adaptation to …
PacC is recognized as an important transcription factor that functions during adaptation to …
Oxygen limitation improves ganoderic acid biosynthesis in submerged cultivation of Ganoderma lucidum
WX Zhang, JJ Zhong - Biotechnology and bioprocess engineering, 2013 - Springer
The effects of oxygen limitation on the production of ganoderic acid (GA), a secondary
metabolite with antitumor activity, and on transcription levels of triterpene biosynthesis …
metabolite with antitumor activity, and on transcription levels of triterpene biosynthesis …
Overexpression of the squalene epoxidase gene alone and in combination with the 3-hydroxy-3-methylglutaryl coenzyme A gene increases ganoderic acid production …
DH Zhang, LX Jiang, N Li, X Yu, P Zhao… - Journal of agricultural …, 2017 - ACS Publications
The squalene epoxidase (SE) gene from the biosynthetic pathway of ganoderic acid (GA)
was cloned and overexpressed in Ganoderma lingzhi. The strain that overexpressed the SE …
was cloned and overexpressed in Ganoderma lingzhi. The strain that overexpressed the SE …
Nitric oxide regulates ganoderic acid biosynthesis by the S‐nitrosylation of aconitase under heat stress in Ganoderma lucidum
R Liu, T Zhu, T Yang, Z Yang, A Ren… - Environmental …, 2021 - Wiley Online Library
Nitric oxide (NO) is an important signalling molecule in stress response of organisms. We
previously reported that NO decreases heat stress (HS)‐induced ganoderic acid (GA) …
previously reported that NO decreases heat stress (HS)‐induced ganoderic acid (GA) …
Cross talk between calcium and reactive oxygen species regulates hyphal branching and ganoderic acid biosynthesis in Ganoderma lucidum under copper stress
T Gao, L Shi, T Zhang, A Ren, A Jiang… - Applied and …, 2018 - Am Soc Microbiol
Ganoderma lucidum is among the best known medicinal basidiomycetes due to its
production of many pharmacologically active compounds. To study the regulatory networks …
production of many pharmacologically active compounds. To study the regulatory networks …
Cross talk between nitric oxide and calcium-calmodulin regulates ganoderic acid biosynthesis in Ganoderma lucidum under heat stress
R Liu, L Shi, T Zhu, T Yang, A Ren, J Zhu… - Applied and …, 2018 - Am Soc Microbiol
We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in
Ganoderma lucidum via Ca2+. Therefore, to further understand the signal-regulating …
Ganoderma lucidum via Ca2+. Therefore, to further understand the signal-regulating …
Molecular characterization and expression analysis of GlHMGS, a gene encoding hydroxymethylglutaryl-CoA synthase from Ganoderma lucidum (Ling-zhi) in …
A Ren, X Ouyang, L Shi, AL Jiang, DS Mu, MJ Li… - World Journal of …, 2013 - Springer
A hydroxymethylglutaryl-CoA synthase gene, designated as GlHMGS (GenBank accession
No. JN391469) involved in ganoderic acid (GA) biosynthesis pathway was cloned from …
No. JN391469) involved in ganoderic acid (GA) biosynthesis pathway was cloned from …
Transcriptome and metabolome analyses reveal transcription factors regulating ganoderic acid biosynthesis in Ganoderma lucidum development
L Meng, R Zhou, J Lin, X Zang, Q Wang… - Frontiers in …, 2022 - frontiersin.org
Ganoderma lucidum is an important medicinal fungus in Asian countries. Ganoderic acid
(GA) is the major variety of bioactive and medicative components in G. lucidum. Biosynthesis …
(GA) is the major variety of bioactive and medicative components in G. lucidum. Biosynthesis …
Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma …
JW Xu, TH Yue, X Yu, P Zhao, T Li… - Microbial …, 2019 - Wiley Online Library
Ganoderic acids produced by Ganoderma exhibit anticancer and antimetastatic activities. A
novel approach by combining Vitreoscilla haemoglobin (VH b) expression and calcium ion …
novel approach by combining Vitreoscilla haemoglobin (VH b) expression and calcium ion …