Alzheimer's disease (AD) is an irreversible neurodegenerative illness and the exact etiology
of the disease remains unknown. It is characterized by long preclinical and prodromal …

Microglia and astrocytes are essential components of brain homeostasis. Interestingly, when
the brain is exposed to adverse conditions, both astrocytes and microglia acquire …

Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

The understanding of the contribution of microglial cells to the onset and/or progression
chronic neurodegenerative diseases is key to identify disease-modifying therapies, given …

Alzheimer's disease (AD) is the most common form of dementia, affecting more than 50
million people worldwide with an estimated increase to 139 million people by 2050. The …

Astrocytes were historically classified as supporting cells; however, it is becoming
increasingly clear that they actively contribute to neuronal functioning under normal and …

Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex
of Alzheimer's disease (AD) patients several decades ago. However, their role in AD …

The neuroinflammatory hypothesis of Alzheimer's disease (AD) was proposed more than 30
years ago. The involvement of the two main types of glial cells microglia and astrocytes, in …

Alzheimer's disease is the leading cause of dementia. Its increased prevalence in
developed countries, due to the sharp rise in ageing populations, presents one of the …