A review of imaging biomarkers of the ocular surface

WW Binotti, B Bayraktutar, MC Ozmen, SM Cox… - Eye & contact …, 2020 - journals.lww.com
A biomarker is a “characteristic that is measured as an indicator of normal biological
processes, pathogenic processes, or responses to an exposure or intervention, including …

Noninvasive imaging of tear film dynamics in eyes with ocular surface disease

NS Abdelfattah, A Dastiridou, SVR Sadda, OL Lee - Cornea, 2015 - journals.lww.com
Purpose: To test the validity of ocular surface assessment tools offered by a corneal
topographer (Oculus Keratograph 5M). Methods: Over 9 months, 296 eyes were imaged and …

[HTML][HTML] Novel approaches for imaging-based diagnosis of ocular surface disease

D Schmidl, A Schlatter, J Chua, B Tan, G Garhöfer… - Diagnostics, 2020 - mdpi.com
Imaging has become indispensable in the diagnosis and management of diseases in the
posterior part of the eye. In recent years, imaging techniques for the anterior segment are …

Correlation between optical coherence tomography–derived assessments of lower tear meniscus parameters and clinical features of dry eye disease

P Nguyen, D Huang, Y Li, SR Sadda, S Ramos… - Cornea, 2012 - journals.lww.com
Purpose: To measure the correlation between subjective symptom score, conventional
clinical tests, and Fourier-domain optical coherence tomography (FD-OCT) of lower tear …

Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography

H Stegmann, VA Dos Santos, A Messner… - Biomedical Optics …, 2019 - opg.optica.org
Many different parameters exist for the investigation of tear film dynamics. We present a new
tear meniscus segmentation algorithm which automatically extracts tear meniscus area …

Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction

Y Bai, W Ngo, S Khanal, KK Nichols, JJ Nichols - The ocular surface, 2021 - Elsevier
Purpose To evaluate the precorneal tear film (PCTF) and lipid layer (TFLL) thicknesses and
thinning rates in meibomian gland dysfunction (MGD) using a combined ultra-high …

Diagnosis of dry eye by tear meniscus measurements using anterior segment swept source optical coherence tomography

R Akiyama, T Usui, S Yamagami - Cornea, 2015 - journals.lww.com
To evaluate the diagnostic power of tear meniscus measurements using anterior segment
swept source optical coherence tomography (SS-OCT) for dry eye and suspected dry eye …

[HTML][HTML] Review of biomarkers in ocular matrices: challenges and opportunities

M Tamhane, S Cabrera-Ghayouri, G Abelian… - Pharmaceutical …, 2019 - Springer
Biomarkers provide a powerful and dynamic approach to improve our understanding of the
mechanisms underlying ocular diseases with applications in diagnosis, disease modulation …

Biomarkers in tears and ocular surface: a window for neurodegenerative diseases

M Roda, C Ciavarella, G Giannaccare… - Eye & Contact …, 2020 - journals.lww.com
Objectives: The purpose of this review is to briefly outline current scientific evidence on the
potential role of tear analysis and ocular surface evaluation in diagnosis and monitoring of …

[HTML][HTML] Pre-corneal tear film thickness in humans measured with a novel technique

K Azartash, J Kwan, JR Paugh, AL Nguyen… - Molecular …, 2011 - ncbi.nlm.nih.gov
Purpose The purpose of this work was to gather preliminary data in normals and dry eye
subjects, using a new, non-invasive imaging platform to measure the thickness of pre …