The potent extracellular actions of purne nucleosides and nucleotides were first recognized
by Drury and Szent-Gyorgyi.'Following this report, there was considerable activity within the …

The release of ATP into the coronary circulation during the vasodilatory response to hypoxia
of the perfused guinea pig heart has been measured by the highly sensitive firefly luciferin …

Adenosine and its phosphorylated nucleotide derivative, ATP, perform essential intracellular
functions in all cells. Because the synthesis of ATP requires the expenditure of metabolic …

Purified endothelial cells isolated from guinea pig hearts by enzymatic perfusion were grown
in monolayer culture and used to test the ability of a variety of vasoactive agents to stimulate …

It is now 75 years since the first recorded administration of adenosine to humans (1310) and
60 years since the first description, by Drury and Szent-Gyorgyi (356), of the actions of …

1. This review focuses on the extracellular actions of ATP and adenosine, and in particular
their role in cardiovascular regulation. 2. ATP serves as a co-transmitter within the …

The isolated thoracic aorta, ear artery and portal vein of the rabbit concentrated tritiated
material on exposure to tritiated adenosine, adenine and its nucleotides. 3H-adenosine was …

Adenosine is known to cause atrioventricular block by slowing conduction through the
atrioventricular node, thereby lengthening the atria to His (AH) interval. To test the …

The Nucleotide Axis Hypothesis, defined and supported herein, proposes that ATP
stimulates the release of vasoactive mediators from endothelium, including ATP itself. Here …

Since THE ORIGINAL study of Drury and Szent-Gyorgyi,'adenosine and adenine
nucleotides have been recognized to have important and potent cardiovascular actions. In …