Lacosamide as Add-On to Monotherapy in Patients with Partial-Onset Seizures: Interim Results of the Post-Marketing VITOBA Study (VImpaT Added to One Baseline …

M Noack-Rink, T Mayer, S Arnold, T Kumke, U Runge - 2012 - AAN Enterprises
Objective: To evaluate the efficacy and safety of lacosamide when added to a single
antiepileptic drug (AED) in patients with partial-onset seizures (POS). Background …

Real‐world antiseizure medication treatment outcomes in drug‐resistant focal epilepsy patients

HT Hatoum, S Arcona, J Mao, S Walton - Epilepsia Open, 2023 - Wiley Online Library
Objective To gather real‐world evidence on antiseizure medications (ASMs) treatment
patterns and related outcomes in patients with drug‐resistant focal epilepsy. Methods …

[HTML][HTML] Clinical outcomes of perampanel vs. lacosamide in cohorts of consecutive patients with severely refractory epilepsies—a monocentric retrospective analysis …

C Kurth, E Kockelmann, BJ Steinhoff - Seizure, 2017 - Elsevier
Purpose Perampanel (PER) and lacosamide (LCM) are antiepileptic drugs (AEDs) approved
for the adjunctive treatment of partial-onset seizures. At the time of market entry, information …

[HTML][HTML] Greater need for treatment optimization in patients with epilepsy initiating adjunctive therapy: Results of a retrospective claims analysis of antiseizure …

GS Connor, DM Labiner, VF Schabert, M Weingarten… - Epilepsy & Behavior, 2024 - Elsevier
Background This retrospective, observational study used US claims data to assess changes
in antiseizure medication (ASM) drug load for a cohort of patients with epilepsy. Methods …

Forgetting to take antiseizure medications is associated with focal to bilateral tonic-clonic seizures, as revealed by a cross-sectional study

H Suzuki, N Mikuni, H Ohnishi, R Yokoyama… - PLoS …, 2020 - journals.plos.org
Objectives To evaluate the effects of nonadherence to antiseizure medications (ASMs) and
clinical characteristics on seizure control, we employed a prospective cohort cross-sectional …

Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide‐naive patients with partial‐onset seizures

NB Fountain, G Krauss, J Isojarvi, D Dilley, P Doty… - …, 2013 - Wiley Online Library
Purpose: To examine the safety and tolerability of rapidly initiating adjunctive lacosamide via
a single intravenous loading dose followed by twice‐daily oral lacosamide in lacosamide …

[HTML][HTML] Healthcare resource utilization and costs before and after lacosamide initiation as adjunctive therapy among patients with epilepsy in the United States

J Fishman, M Martin, DM Labiner, CR Lew… - Epilepsy & Behavior, 2019 - Elsevier
Objective The objective of this study was to evaluate all-cause and epilepsy-specific
healthcare resource utilization and costs following lacosamide (LCM) initiation as adjunctive …

Persistence with antiepileptic drugs in epilepsy patients treated in neurological practices in Germany

L Jacob, HM Hamer, K Kostev - Epilepsy & Behavior, 2017 - Elsevier
Objective The goal of this study was to analyze the persistence with antiepileptic drugs
(AED) and associated factors in patients followed in neurological practices in Germany …

Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8 years

W Rosenfeld, NB Fountain, G Kaubrys… - Epilepsy & Behavior, 2014 - Elsevier
Long-term (up to 8 years of exposure) safety and efficacy of the antiepileptic drug
lacosamide was evaluated in this open-label extension trial (SP615 [ClinicalTrials. gov …

Perampanel and lacosamide monotherapy in pediatric patients with newly diagnosed focal epilepsy: a prospective study evaluating efficacy, tolerability, and behavior

R Zhou, R Qu, M Liu, DP Huang, JY Zhou, Y Chen… - Epilepsy & Behavior, 2023 - Elsevier
Purpose Perampanel (PER) and lacosamide (LCM) are the new third-generation anti-
seizure medications (ASMs) that were approved for the monotherapy of focal epilepsy in …