Long‐term safety and efficacy in patients with uncontrolled partial‐onset seizures treated with adjunctive lacosamide: results from a Phase III open‐label extension …

A Husain, S Chung, E Faught, J Isojarvi, C McShea… - …, 2012 - Wiley Online Library
Purpose: To evaluate the long‐term (up to 5 years exposure) safety and efficacy of
lacosamide as adjunctive therapy in patients with uncontrolled partial‐onset seizures taking …

Patterns of antiseizure medication utilization in the Human Epilepsy Project

J Fox, S Barnard, SH Agashe, MG Holmes, B Gidal… - …, 2023 - Wiley Online Library
Objective This study was undertaken to ascertain the natural history and patterns of
antiseizure medication (ASM) use in newly diagnosed focal epilepsy patients who were …

Lacosamide as adjunctive therapy for partial-onset epileptic seizures: a review of the clinical and economic literature

S Simoens - Current medical research and opinion, 2011 - Taylor & Francis
Objective: This article provides a short but comprehensive pharmacotherapeutic update of
adjunctive therapy with lacosamide for partial-onset seizures in adult patients. Research …

Clinical impact of the dose and blood concentration of lacosamide in Japanese pediatric patients with epilepsy: a cohort study

N Ishikawa, Y Eguchi, H Izumo, Y Tateishi, H Tani… - Epilepsy & Behavior, 2022 - Elsevier
Purpose The relationship between treatment efficacy/tolerability and the dose/blood
concentration of lacosamide (LCM) was investigated in a clinical cohort of Japanese …

Efficacy, safety, and tolerability of lacosamide monotherapy versus controlled-release carbamazepine in patients with newly diagnosed epilepsy: a phase 3 …

M Baulac, F Rosenow, M Toledo, K Terada… - The Lancet …, 2017 - thelancet.com
Background Further options for monotherapy are needed to treat newly diagnosed epilepsy
in adults. We assessed the efficacy, safety, and tolerability of lacosamide as a first-line …

Adjunctive lacosamide—5 years' clinical experience

LJ Stephen, K Kelly, P Parker, MJ Brodie - Epilepsy research, 2014 - Elsevier
Summary Purpose In 2008, lacosamide (LCM) was licensed in Europe for the adjunctive
treatment of focal-onset seizures. At that time a prospective audit was initiated at the Western …

The Effectivety, Safety and Tolerability Profile of Lacosamide Therapy in Refractory Epilepsy: Premarketing Experience

F Genc, FEU Tokuc, G Akca, Y Aydemir, G Kutlu… - 2014 - acikerisim.mu.edu.tr
Objectives: Lacosamide is a novel antiepileptic drug used in partial refractory epilepsy
patients. Methods: We searched retrospectively 1100 patients who have follow up in Antalya …

[HTML][HTML] The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions

J Brenner, HJM Majoie, S van Beek, JA Carpay - Seizure, 2017 - Elsevier
Purpose We describe the effectiveness of lacosamide as adjunctive therapy in patients with
epilepsy and an intellectual disability. This information is relevant, as few data exist …

[HTML][HTML] Long-term efficacy and safety of lacosamide monotherapy in the treatment of partial-onset seizures: a multicenter evaluation

BG Giráldez, R Toledano, I García-Morales… - Seizure, 2015 - Elsevier
Purpose The goal of this study is to report the efficacy and tolerability of lacosamide (LCM)
monotherapy, as first-line and conversion regimens, in the treatment of patients with partial …

Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany

T Wehner, S Bauer, HM Hamer, K Hattemer… - Epilepsy & Behavior, 2009 - Elsevier
We report our 6months of experience with adjunctive lacosamide in 25 patients with
pharmacoresistant focal epilepsy. Baseline characteristics of our patients were similar to …