[HTML][HTML] Considerations of timing post-ovariectomy in mice and rats in studying anxiety-and depression-like behaviors associated with surgical menopause in women

JF Rodríguez-Landa - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Menopause is a clinical term that indicates the end of the reproductive period of women that
occurs naturally; however, it can be induced by bilateral oophorectomy, which is commonly …

[HTML][HTML] Ovariectomy results in variable changes in nociception, mood and depression in adult female rats

LH Li, ZC Wang, J Yu, YQ Zhang - PloS one, 2014 - journals.plos.org
Decline in the ovarian hormones with menopause may influence somatosensory, cognitive,
and affective processing. The present study investigated whether hormonal depletion alters …

Long-term ovariectomy increases anxiety-and despair-like behaviors associated with lower Fos immunoreactivity in the lateral septal nucleus in rats

A Puga-Olguín, JF Rodríguez-Landa… - Behavioural Brain …, 2019 - Elsevier
In woman, surgical menopause is associated with anxiety and depression symptoms.
Ovariectomy in rats has been proposed as an experimental model of surgical menopause …

Prolame ameliorates anxiety and spatial learning and memory impairment induced by ovariectomy in rats

I Nissen, FS Estrada, AT Nava-Kopp, C Irles… - Physiology & …, 2012 - Elsevier
N-(3-hydroxy-1, 3, 5 (10) estratrien-17beta-yl)-3-hydroxypropylamine (17β aminoestrogen,
prolame) is a steroidal compound with weak estrogen-related trophic-proliferative effects in …

Decreased voluntary activity and amygdala levels of serotonin and dopamine in ovariectomized rats

N Izumo, Y Ishibashi, M Ohba, T Morikawa… - Behavioural brain …, 2012 - Elsevier
Estrogen is involved in numerous activities in the brain, such as learning, memory, fear,
anxiety and mood. However, little is known about the pathways involved in the effects of …

[HTML][HTML] Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model

DC Baek, JY Kang, JS Lee, EJ Lee, CG Son - Scientific Reports, 2024 - nature.com
The high risk of neurological disorders in postmenopausal women is an emerging medical
issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of …

[HTML][HTML] Effects of long-term ovariectomy on anxiety and behavioral despair in rats

G De Chaves, M Moretti, AA Castro, W Dagostin… - Physiology & …, 2009 - Elsevier
Clinical and pre-clinical findings point to the critical role of ovarian hormones in modulating
anxiety and depressive symptoms in female. However, few studies investigated the effects of …

[HTML][HTML] Ovariectomy induces microglial cell activation and inflammatory response in rat prefrontal cortices to accelerate the chronic unpredictable stress-mediated …

F Ge, H Yang, W Lu, H Shi, Q Chen, Y Luo… - BioMed Research …, 2020 - hindawi.com
Perimenopausal women are associated with increased risks of depression and anxiety,
which may be potentially related to the lack of ovarian hormone with antidepression activity …

Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats

J Pandaranandaka, S Poonyachoti… - Physiology & …, 2006 - Elsevier
Anxiety is a symptom reflecting the dysregulation of monoaminergic neurotransmitters which
may be modulated by estrogen. In our current study, we investigated the effects of chronic …

[HTML][HTML] The Phytoestrogen Genistein Produces Similar Effects as 17β-Estradiol on Anxiety-Like Behavior in Rats at 12 Weeks after Ovariectomy

JF Rodríguez-Landa, J Cueto-Escobedo… - BioMed Research …, 2017 - hindawi.com
The phytoestrogen genistein produces anxiolytic-like effects in ovariectomized rats, which
highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal …