[HTML][HTML] Oxidative stress-based therapeutics in COPD

PJ Barnes - Redox biology, 2020 - Elsevier
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

Antioxidant therapeutic targets in COPD

I Rahman, I Kilty - Current Drug Targets, 2006 - ingentaconnect.com
Oxidative stress and chronic inflammation are important features in the pathogenesis of
chronic obstructive pulmonary disease (COPD). Oxidative stress has important …

Antioxidant pharmacological therapies for COPD

I Rahman, W MacNee - Current Opinion in Pharmacology, 2012 - Elsevier
Increased oxidative stress occurs in the lungs and systemically in COPD, which plays a role
in many of the pathogenic mechanisms in COPD. Hence, targeting local lung and systemic …

[HTML][HTML] Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities

I Bernardo, S Bozinovski, R Vlahos - Pharmacology & therapeutics, 2015 - Elsevier
Chronic obstructive pulmonary disease (COPD) is an incurable global health burden and is
characterised by progressive airflow limitation and loss of lung function. In addition to the …

Oxidants and COPD

W MacNee - Current Drug Targets-Inflammation & Allergy, 2005 - ingentaconnect.com
Smoking is the main etiologic factor in chronic obstructive pulmonary disease (COPD).
Cigarette smoke produces an enormous oxidant burden on the lungs, which is exacerbated …

Oxidative stress in COPD

PA Kirkham, PJ Barnes - Chest, 2013 - Elsevier
Oxidative stress is now recognized as a major predisposing factor in the pathogenesis of
COPD. Existing therapies for COPD are ineffective at halting disease progression, with …

Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?

W MacNee, I Rahman - Trends in molecular medicine, 2001 - cell.com
There is now considerable evidence for an increased oxidant burden in patients with chronic
obstructive pulmonary disease (COPD). Oxidative stress is a critical feature in the …

The role of oxidative stress in the pathogenesis of COPD: implications for therapy

I Rahman - Treatments in respiratory medicine, 2005 - Springer
Chronic inflammation and oxidative stress are important features in the pathogenesis of
COPD. The increased oxidative stress in patients with COPD is the result of an increased …

COPD: balancing oxidants and antioxidants

BM Fischer, JA Voynow, AJ Ghio - International journal of chronic …, 2015 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses
in the world. The disease encompasses emphysema, chronic bronchitis, and small airway …

[HTML][HTML] Oxidative stress in chronic obstructive pulmonary disease

PJ Barnes - Antioxidants, 2022 - mdpi.com
There is a marked increase in oxidative stress in the lungs of patients with COPD, as
measured by increased exhaled 8-isoprostane, ethane, and hydrogen peroxide in the …