Plant genomes remain highly fragmented and are often characterized by hundreds to
thousands of assembly gaps. Here, we report chromosome-level reference and phased …

Abstract The Rubiaceae species, Ophiorrhiza pumila, accumulates camptothecin, an anti-
cancer alkaloid with a potent DNA topoisomerase I inhibitory activity, as well as …

Camptotheca acuminata is 1 of a limited number of species that produce camptothecin, a
pentacyclic quinoline alkaloid with anti-cancer activity due to its ability to inhibit DNA …

Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …

Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic
antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by …

For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM)
to support their sessile lifestyles through continuous biochemical pathway innovation. While …

The medicinal plant Madagascar periwinkle, C atharanthus roseus (L.) G. Don, produces
hundreds of biologically active monoterpene‐derived indole alkaloid (MIA) metabolites and …

Salvia miltiorrhiza Bunge (Danshen) is a medicinal plant of the Lamiaceae family, and its
dried roots have long been used in traditional Chinese medicine with hydrophilic phenolic …

Background Camptotheca acuminata is a Nyssaceae plant, often called the" happy tree",
which is indigenous in Southern China. C. acuminata produces the terpenoid indole …

The medicinal plant Madagascar periwinkle (Catharanthus roseus) synthesizes numerous
terpenoid indole alkaloids (TIAs), such as the anticancer drugs vinblastine and vincristine …