[HTML][HTML] Coumarin derivatives as acetyl-and butyrylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study
MN Abu-Aisheh, A Al-Aboudi, MS Mustafa… - Heliyon, 2019 - cell.com
Alzheimer's disease is an irreversible and progressive brain disease that can cause
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …
Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives
Cholinesterase enzymes are promising drug targets for the symptomatic treatment of
Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading …
Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading …
Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives
Alzheimer's disease is among the most widespread neurodegenerative disorder.
Cholinesterases (ChEs) play an indispensable role in the control of cholinergic transmission …
Cholinesterases (ChEs) play an indispensable role in the control of cholinergic transmission …
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
Abstract Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are
interesting compounds for different therapeutic applications, among which Alzheimer's …
interesting compounds for different therapeutic applications, among which Alzheimer's …
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
Design, Synthesis, Biological Evaluation, and Molecular Modeling of Coumarin–P iperazine Derivatives as Acetylcholinesterase Inhibitors
RP Modh, SP Kumar, YT Jasrai… - Archiv der …, 2013 - Wiley Online Library
Acetylcholinesterase (AChE) is an important drug target for the treatment of Alzheimer's
disease. A novel series of coumarin–piperazine derivatives were synthesized and their …
disease. A novel series of coumarin–piperazine derivatives were synthesized and their …
Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors
New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl
chains and/or the heterocycle nucleus were synthesized and in vitro tested as …
chains and/or the heterocycle nucleus were synthesized and in vitro tested as …
Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition
P Baruah, G Basumatary, SO Yesylevskyy… - Journal of …, 2019 - Taylor & Francis
The inhibitory efficacy of two substituted coumarin derivatives on the activity of
neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer …
neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer …
Characterization of the interactions between coumarin-derivatives and acetylcholinesterase: Examination by NMR and docking simulations
NU Tanoli, SAK Tanoli, AG Ferreira… - Journal of Molecular …, 2018 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia and a significant
threat to the elderly populations, especially in the Western world. The rapid hydrolysis of the …
threat to the elderly populations, especially in the Western world. The rapid hydrolysis of the …
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