Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment

M Martínez-Álvaro, A Zubiri-Gaitán… - Communications …, 2021 - nature.com
Our study provides an exhaustive comparison of the microbiome core functionalities
(captured by 3,936 microbial gene abundances) between hosts with divergent genotypes for …

[HTML][HTML] Gut microbiome mediates host genomic effects on phenotypes: a case study with fat deposition in pigs

F Tiezzi, J Fix, C Schwab, C Shull… - Computational and …, 2021 - Elsevier
A large number of studies have highlighted the importance of gut microbiome composition in
shaping fat deposition in mammals. Several studies have also highlighted how host genome …

[HTML][HTML] Multi-omics analysis reveals gut microbiota-induced intramuscular fat deposition via regulating expression of lipogenesis-associated genes

C Xie, J Teng, X Wang, B Xu, Y Niu, L Ma, X Yan - Animal Nutrition, 2022 - Elsevier
The gut microbiome has great effects on the digestion, absorption, and metabolism of lipids.
However, the microbiota composition that can alter the fat deposition and the meat quality of …

Genetic and microbiome influence on lipid metabolism and dyslipidemia

ML Matey-Hernandez, FMK Williams… - Physiological …, 2018 - journals.physiology.org
Disruption in the metabolism of lipids is broadly classified under dyslipidemia and relates to
the concentration of lipids in the blood. Dyslipidemia is a predictor of cardio-metabolic …

Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics

A O'Connor, PM Quizon, JE Albright, FT Lin… - Mammalian …, 2014 - Springer
Intestinal microbial community structure is driven by host genetics in addition to
environmental factors such as diet. In comparison with environmental influences, the effect …

Molecular ecological tools to decipher the role of our microbial mass in obesity

GDA Hermes, EG Zoetendal… - Beneficial …, 2015 - wageningenacademic.com
After birth, our gastrointestinal (GI) tract is colonised by a highly complex assemblage of
microbes, collectively termed the GI microbiota, that develops intimate interactions with our …

Integrative longitudinal analysis of metabolic phenotype and microbiota changes during the development of obesity

KV Higgins, LN Woodie, H Hallowell… - Frontiers in Cellular …, 2021 - frontiersin.org
Obesity has increased at an alarming rate over the past two decades in the United States. In
addition to increased body mass, obesity is often accompanied by comorbidities such as …

[HTML][HTML] Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health

CWY Ha, YY Lam, AJ Holmes - World Journal of Gastroenterology …, 2014 - ncbi.nlm.nih.gov
Gut microbes comprise a high density, biologically active community that lies at the interface
of an animal with its nutritional environment. Consequently their activity profoundly …

Microbiome-driven breeding strategy potentially improves beef fatty acid profile benefiting human health and reduces methane emissions

M Martínez-Álvaro, J Mattock, M Auffret, Z Weng… - Microbiome, 2022 - Springer
Background Healthier ruminant products can be achieved by adequate manipulation of the
rumen microbiota to increase the flux of beneficial fatty acids reaching host tissues. Genomic …

Coordinated regulation of the metabolome and lipidome at the host-microbial interface

F Bäckhed, PA Crawford - Biochimica et Biophysica Acta (BBA)-Molecular …, 2010 - Elsevier
The creative use of gnotobiotic animals, coupled with the development of modern
metagenomic sequencing platforms and metabolomic profiling of biospecimens, has …