Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

The caspases are unique proteases that mediate the major morphological changes of
apoptosis and various other cellular remodeling processes. As we catalog and study the …

At present, mammalian caspases comprise a group of at least 13 protease members which
either generate mature pro-inflammatory cytokines or promote apoptosis (Cohen, 1997; …

Apoptosis or programmed cell death is an active form of cell death which is essential for
tissue homeostasis. Many proteins are involved in the molecular signal transduction of …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Caspases are a family of cysteine aspartyl proteases mostly involved in the execution of
apoptotic cell death and in regulating inflammation. This article focuses primarily on the …

Caspases orchestrate the controlled demise of a cell after an apoptotic signal through
specific protease activity and cleavage of many substrates altering protein function and …

The complex process of apoptosis is orchestrated by caspases, a family of cysteine
proteases with unique substrate specificities. Accumulating evidence suggests that cell …

Apoptosis, a highly controlled mode of cell death, is utilized to eliminate superfluous, aged,
injured or infected cells from the body. Caspases, a family of aspartic acid-specific …