Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the
major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we …

Chloroquine resistance in Plasmodium falciparum is primarily conferred by mutations in
pfcrt. Parasites resistant to chloroquine can display hypersensitivity to other antimalarials; …

Genetic, physiological and pharmacological studies are gradually revealing the molecular
basis of chloroquine resistance (CQR) in the malaria parasite, Plasmodium falciparum …

Recent studies have highlighted the importance of a parasite protein referred to as the
chloroquine resistance transporter (PfCRT) in the molecular basis of Plasmodium falciparum …

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant
of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are …

Mutations in the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT)
can result in verapamil‐reversible CQ resistance and altered susceptibility to other …

Chloroquine (CQ), an antimalarial drug with a long history, now frequently fails in the field
owing to the rapid spread of resistant Plasmodium falciparum strains. CQ resistance is …

The prevention and treatment of malaria is heavily dependent on antimalarial drugs.
However, beginning with the emergence of chloroquine (CQ)-resistant Plasmodium …

Resistance to quinoline antimalarials, especially to chloroquine and mefloquine has had a
major impact on the treatment of malaria worldwide. In the period since 2000, significant …