Interaction of the Lyme disease spirochete with its tick vector

MJ Caimano, D Drecktrah, F Kung… - Cellular …, 2016 - Wiley Online Library
Borrelia burgdorferi, the causative agent of Lyme disease (along with closely related
genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in …

Borrelia burgdorferi: Carbon Metabolism and the Tick-Mammal Enzootic Cycle

A Corona, I Schwartz - Microbiology spectrum, 2015 - Am Soc Microbiol
Borrelia burgdorferi, the spirochetal agent of Lyme disease, is a zoonotic pathogen that is
maintained in a natural cycle that typically involves mammalian reservoir hosts and a tick …

[HTML][HTML] Borrelia burgdorferi–traveling incognito?

E Fikrig, S Narasimhan - Microbes and infection, 2006 - Elsevier
We outline in this review how Borrelia burgdorferi, the causative agent of Lyme disease,
moves from the tick to the vertebrate host, and what molecules are potentially involved in this …

Borrelia burgdorferi malQ mutants utilize disaccharides and traverse the enzootic cycle

LL Hoon-Hanks, EA Morton… - FEMS Immunology & …, 2012 - academic.oup.com
Borrelia burgdorferi, the causative agent of Lyme disease, cycles in nature between a
vertebrate host and a tick vector. We demonstrate that B. burgdorferi can utilize several …

[HTML][HTML] Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

JD Radolf, MJ Caimano, B Stevenson… - Nature reviews …, 2012 - nature.com
In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia
burgdorferi, has risen from relative obscurity to become a global public health problem and a …

[HTML][HTML] Adaptation of Borrelia burgdorferi in the vector and vertebrate host

U Pal, E Fikrig - Microbes and infection, 2003 - Elsevier
Borrelia burgdorferi sensu lato is the causative agent of Lyme disease, which afflicts both
humans and some domestic animals. B. burgdorferi, a highly evolved extracellular …

Interactions between Borrelia burgdorferi and its hosts across the enzootic cycle

JD Helble, JE McCarthy, LT Hu - Parasite immunology, 2021 - Wiley Online Library
The bacterial pathogen Borrelia burgdorferi is the causative agent of Lyme disease and is
transmitted to humans through an Ixodes tick vector. B. burgdorferi is able to survive in both …

[HTML][HTML] Interactions between Borrelia burgdorferi and ticks

C Kurokawa, GE Lynn, JHF Pedra, U Pal… - Nature Reviews …, 2020 - nature.com
Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate
hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic …

Pathogenicity and virulence of Borrelia burgdorferi

M Strnad, N Rudenko, ROM Rego - Virulence, 2023 - Taylor & Francis
Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …

The consistent tick-vertebrate infectious cycle of the Lyme disease spirochete enables Borrelia burgdorferi to control protein expression by monitoring its physiological …

B Stevenson, AC Krusenstjerna… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT The Lyme disease spirochete, Borrelia burgdorferi, persists in nature by
alternatingly cycling between ticks and vertebrates. During each stage of the infectious …