Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular
mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently …

High glucose-induced cardiomyocyte death is a common symptom in advanced-stage
diabetic patients, while its metabolic mechanism is still poorly understood. The aim of this …

High glucose and high fat are important inducements for the development and progression
of diabetic cardiopathy. Salvianolic acid B (SAB), which is the most abundant and bioactive …

Increased levels of free fatty acids (FFAs), specifically saturated free fatty acids such as
palmitate are associated with insulin resistance of muscle, fat and liver. Skeletal muscle …

Octaphlorethol A (OPA), a type of phlorotannin isolated from Ishige foliacea has been shown
to have antidiabetic activities. However, the mechanism of action of OPA in type 2 diabetes …

The modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is increasingly
recognized as an important posttranslational modification that modulates cellular function …

Blood glucose fluctuations, also referred to as intermittent high glucose, have been validated
to be more harmful than sustained high glucose in exacerbating pancreatic dysfunction by …

Scope: Glucose uptake in skeletal muscle is crucial for glucose homeostasis. Methods and
results: Insulin and muscle contraction increase glucose uptake accompanied by the …

Background Asiatic acid is a reported glycogen phosphorylase inhibitor derived from the
tropical medicinal plant Centella asiatica and exhibits myocardial protection both in vivo and …

Background and Aim Type 2 diabetes mellitus (T2DM), a complex metabolic disease, has
become a major public health issue around the world. Hydroxysafflor yellow A (HSYA) is the …