Dietary preferences of Brattleboro rats correlated with an overexpression of galanin in the hypothalamus

M Odorizzi, JP Max, P Tankosic… - European Journal of …, 1999 - Wiley Online Library
Galanin (GAL) is a neuropeptide cosynthesized with vasopressin (AVP) in neurons of the
hypothalamo‐neurohypophysial system. It increases food intake when injected into the brain …

Galanin in the hypothalamus of fed and fasted lean and obese Zucker rats

B Beck, A Burlet, JP Nicolas, C Burlet - Brain research, 1993 - Elsevier
Abstract Galanin (GAL), a 29 aminoacid peptide, is widely distributed in the central nervous
system and especially in the hypothalamus. It strongly stimulates food intake when it is …

Hypothalamic galanin and plasma leptin and ghrelin in the maintenance of energy intake in the Brattleboro rat

B Beck, JP Max - Biochemical and biophysical research communications, 2007 - Elsevier
Galanin, ghrelin, and leptin are three peptides involved in feeding regulation and more
particularly in fat intake. The Brattleboro (di/di) rat is a genetic model of diabetes insipidus …

Hypothalamic galanin is up-regulated during hyperphagia and increased body weight gain induced by disruption of signaling in the ventromedial nucleus☆

MG Dube, SP Kalra, PS Kalra - Peptides, 2000 - Elsevier
Disruption of signaling in the ventromedial nucleus (VMN) by colchicine (COL) produces
transient (4 days) hyperphagia and weight gain. Microinjection of galanin into various …

Obesity on a high-fat diet: role of hypothalamic galanin in neurons of the anterior paraventricular nucleus projecting to the median eminence

SF Leibowitz, A Akabayashi, J Wang - Journal of Neuroscience, 1998 - Soc Neuroscience
Previous studies have suggested that the peptide galanin (GAL) in the hypothalamus is
related to the preference of an animal for dietary fat. The present report investigates this …

Hypothalamic galanin: control by signals of fat metabolism

J Wang, A Akabayashi, HJ Yu, J Dourmashkin… - Brain research, 1998 - Elsevier
The peptide, galanin (GAL), is known to stimulate eating behavior, reduce energy
expenditure and affect the release of metabolic hormones. Further, the activity of this peptide …

Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis

SF Leibowitz - Neuropeptides, 2005 - Elsevier
Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties
and functions from other feeding stimulants, eg, neuropeptide Y and agouti-related protein …

Galanin receptor antagonists decrease fat preference in Brattleboro rat

M Odorizzi, B Fernette, E Angel, C Burlet, P Tankosic… - …, 2002 - Elsevier
The Brattleboro rat eats spontaneously 46% of its diet per day in fat when given a choice of
carbohydrate, protein and fat. An overexpression of galanin (GAL) has been also observed …

Galanin-containing neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain.

A Akabayashi, JI Koenig, Y Watanabe… - Proceedings of the …, 1994 - National Acad Sciences
The physiological function of the peptide galanin (Gal) remains to be established. It is known
to exist in high concentrations within the hypothalamus and to modulate the secretion of …

Regulation of galanin gene expression in the hypothalamic paraventricular nucleus of the obese Zucker rat by manipulation of dietary macronutrients

JG Mercer, CB Lawrence, T Atkinson - Molecular brain research, 1996 - Elsevier
Lean and obese male Zucker rats were fed high fat (72% of energy as fat), high
carbohydrate (66% of energy as carbohydrate) or intermediate diets for 4 weeks …