Cardiac ATP production is tightly regulated in order to satisfy the evolving energetic
requirements imposed by different cues during health and pathological conditions. In order …

The mitochondrion is the main site for ATP production in the adult heart and comprises up to
40% of the cardiac myocyte volume. It is now recognized that a complex network of nuclear …

The mitochondrion is a complex organelle that serves essential roles in energy transduction,
ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network …

The heart is an omnivore organ that requires constant energy production to match its
functional demands. In the adult heart, adenosine‐5′‐triphosphate (ATP) production …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

Cardiac performance depends on a fine balance between the work the heart has to perform
to satisfy the needs of the body and the energy that it is able to produce. Thus, energy …

Mitochondria in the adult mammalian heart have a tremendous capacity for oxidative
metabolism, and the conversion of energy by these pathways is critical for proper cardiac …

The ultrastructure of the cardiac myocyte is remarkable for the high density of mitochondria
tightly packed between sarcomeres. This structural organization is designed to provide …

The mammalian myocardium is an omnivorous organ that relies on multiple substrates in
order to fulfill its tremendous energy demands. Cardiac energy metabolism preference is …

The heart is composed of a heterogeneous mixture of cellular components perfectly
intermingled and able to integrate common environmental signals to ensure proper cardiac …